Gene Review:
Sirpa - signal-regulatory protein alpha
Mus musculus
Synonyms:
AI835480, Bit, Brain Ig-like molecule with tyrosine-based activation motifs, CD172 antigen-like family member A, CD172a, ...
- Negative regulation of platelet clearance and of the macrophage phagocytic response by the transmembrane glycoprotein SHPS-1. Yamao, T., Noguchi, T., Takeuchi, O., Nishiyama, U., Morita, H., Hagiwara, T., Akahori, H., Kato, T., Inagaki, K., Okazawa, H., Hayashi, Y., Matozaki, T., Takeda, K., Akira, S., Kasuga, M. J. Biol. Chem. (2002)
- Resistance of B16 melanoma cells to CD47-induced negative regulation of motility as a result of aberrant N-glycosylation of SHPS-1. Ogura, T., Noguchi, T., Murai-Takebe, R., Hosooka, T., Honma, N., Kasuga, M. J. Biol. Chem. (2004)
- Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia. Olsson, M., Bruhns, P., Frazier, W.A., Ravetch, J.V., Oldenborg, P.A. Blood (2005)
- Critical role for protein tyrosine phosphatase SHP-1 in controlling infection of central nervous system glia and demyelination by Theiler's murine encephalomyelitis virus. Massa, P.T., Ropka, S.L., Saha, S., Fecenko, K.L., Beuler, K.L. J. Virol. (2002)
- CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligand-independent mechanisms. Poe, J.C., Fujimoto, Y., Hasegawa, M., Haas, K.M., Miller, A.S., Sanford, I.G., Bock, C.B., Fujimoto, M., Tedder, T.F. Nat. Immunol. (2004)
- CD47-signal regulatory protein alpha (SIRPalpha) regulates Fcgamma and complement receptor-mediated phagocytosis. Oldenborg, P.A., Gresham, H.D., Lindberg, F.P. J. Exp. Med. (2001)
- SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility. Inagaki, K., Yamao, T., Noguchi, T., Matozaki, T., Fukunaga, K., Takada, T., Hosooka, T., Akira, S., Kasuga, M. EMBO J. (2000)
- Negative regulation of phagocytosis in macrophages by the CD47-SHPS-1 system. Okazawa, H., Motegi, S., Ohyama, N., Ohnishi, H., Tomizawa, T., Kaneko, Y., Oldenborg, P.A., Ishikawa, O., Matozaki, T. J. Immunol. (2005)
- Ectodomain shedding of SHPS-1 and its role in regulation of cell migration. Ohnishi, H., Kobayashi, H., Okazawa, H., Ohe, Y., Tomizawa, K., Sato, R., Matozaki, T. J. Biol. Chem. (2004)
- Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 regulates the migration of Langerhans cells from the epidermis to draining lymph nodes. Fukunaga, A., Nagai, H., Noguchi, T., Okazawa, H., Matozaki, T., Yu, X., Lagenaur, C.F., Honma, N., Ichihashi, M., Kasuga, M., Nishigori, C., Horikawa, T. J. Immunol. (2004)
- Expression of a synapse-associated membrane protein, P84/SHPS-1, and its ligand, IAP/CD47, in mouse retina. Mi, Z.P., Jiang, P., Weng, W.L., Lindberg, F.P., Narayanan, V., Lagenaur, C.F. J. Comp. Neurol. (2000)
- SHPS-1 induces aggregation of Ba/F3 pro-B cells via an interaction with CD47. Babic, I., Schallhorn, A., Lindberg, F.P., Jirik, F.R. J. Immunol. (2000)
- SHP-2 complex formation with the SHP-2 substrate-1 during C2C12 myogenesis. Kontaridis, M.I., Liu, X., Zhang, L., Bennett, A.M. J. Cell. Sci. (2001)
- Lethal autoimmune hemolytic anemia in CD47-deficient nonobese diabetic (NOD) mice. Oldenborg, P.A., Gresham, H.D., Chen, Y., Izui, S., Lindberg, F.P. Blood (2002)
- A role for SHPS-1/SIRPalpha1 in IL-1beta- and TNFalpha-dependent signaling. Ruhul Amin, A.R., Machida, K., Oshima, K., Oo, M.L., Thant, A.A., Senga, T., Matsuda, S., Akhand, A.A., Maeda, A., Kurosaki, T., Hamaguchi, M. Oncogene (2002)
- The PLC-PKC cascade is required for IL-1beta-dependent Erk and Akt activation: their role in proliferation. Amin, A.R., Ichigotani, Y., Oo, M.L., Biswas, M.H., Yuan, H., Huang, P., Mon, N.N., Hamaguchi, M. Int. J. Oncol. (2003)
- B cell defects in SLP65/BLNK-deficient mice can be partially corrected by the absence of CD22, an inhibitory coreceptor for BCR signaling. Gerlach, J., Ghosh, S., Jumaa, H., Reth, M., Wienands, J., Chan, A.C., Nitschke, L. Eur. J. Immunol. (2003)
- Attenuation of phagocytosis of xenogeneic cells by manipulating CD47. Wang, H., Verhalen, J., Madariaga, M.L., Xiang, S., Wang, S., Lan, P., Oldenborg, P.A., Sykes, M., Yang, Y.G. Blood (2007)
- The murine P84 neural adhesion molecule is SHPS-1, a member of the phosphatase-binding protein family. Comu, S., Weng, W., Olinsky, S., Ishwad, P., Mi, Z., Hempel, J., Watkins, S., Lagenaur, C.F., Narayanan, V. J. Neurosci. (1997)