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Gene Review

Frs2  -  fibroblast growth factor receptor substrate 2

Mus musculus

Synonyms: 4732458E18, C330018A15Rik, FGFR substrate 2, FGFR-signaling adaptor SNT, FRS2-alpha, ...
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High impact information on Frs2


Biological context of Frs2

  • Here we report that cell cycle inducer Cks1, which triggers ubiquitination and degradation of p27(Kip1), associates with the unphosphorylated form of FGFR substrate 2 (FRS2), an adaptor protein that is phosphorylated by FGFR kinases and recruits downstream signaling molecules [6].

Other interactions of Frs2

  • Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development [4].
  • We report that Frs2alpha and Frs2beta have distinct spatio-temporal expression patterns in mouse embryos [7].


  1. The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development. Gotoh, N., Manova, K., Tanaka, S., Murohashi, M., Hadari, Y., Lee, A., Hamada, Y., Hiroe, T., Ito, M., Kurihara, T., Nakazato, H., Shibuya, M., Lax, I., Lacy, E., Schlessinger, J. Mol. Cell. Biol. (2005) [Pubmed]
  2. Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts. Kontaridis, M.I., Liu, X., Zhang, L., Bennett, A.M. Mol. Cell. Biol. (2002) [Pubmed]
  3. Identification of a fibroblast growth factor receptor 1 splice variant that inhibits pancreatic cancer cell growth. Liu, Z., Neiss, N., Zhou, S., Henne-Bruns, D., Korc, M., Bachem, M., Kornmann, M. Cancer Res. (2007) [Pubmed]
  4. Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development. Hoch, R.V., Soriano, P. Development (2006) [Pubmed]
  5. The signaling adapters fibroblast growth factor receptor substrate 2 and 3 are activated by the thyroid TRK oncoproteins. Ranzi, V., Meakin, S.O., Miranda, C., Mondellini, P., Pierotti, M.A., Greco, A. Endocrinology (2003) [Pubmed]
  6. Direct cell cycle regulation by the fibroblast growth factor receptor (FGFR) kinase through phosphorylation-dependent release of Cks1 from FGFR substrate 2. Zhang, Y., Lin, Y., Bowles, C., Wang, F. J. Biol. Chem. (2004) [Pubmed]
  7. FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts. Gotoh, N., Laks, S., Nakashima, M., Lax, I., Schlessinger, J. FEBS Lett. (2004) [Pubmed]
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