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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

psh  -  persephone

Drosophila melanogaster

Synonyms: CG6367, Dmel\CG6367, Psh, SP28, Serine protease persephone, ...
 
 
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Disease relevance of psh

 

High impact information on psh

  • The Drosophila Persephone protease activates the Toll pathway when proteolytically matured by the secreted fungal virulence factor PR1 [2].
  • These data show that Necrotic is likely to inhibit a wide range of proteases in Drosophila and that Nec has the specificity requirements to act as the physiological inhibitor of Persephone in vivo [3].
  • We identified homologs of D. melanogaster persephone, M. sexta HP14, PAP-1 and SPH-1 [4].
 

Associations of psh with chemical compounds

  • We show that ethylmethane sulfonate-induced mutations in the persephone gene, which encodes a previously unknown serine protease, block induction of the Toll pathway by fungi and resistance to this type of infection [5].

References

  1. Immune challenge induces N-terminal cleavage of the Drosophila serpin Necrotic. Pelte, N., Robertson, A.S., Zou, Z., Belorgey, D., Dafforn, T.R., Jiang, H., Lomas, D., Reichhart, J.M., Gubb, D. Insect Biochem. Mol. Biol. (2006) [Pubmed]
  2. Dual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors. Gottar, M., Gobert, V., Matskevich, A.A., Reichhart, J.M., Wang, C., Butt, T.M., Belvin, M., Hoffmann, J.A., Ferrandon, D. Cell (2006) [Pubmed]
  3. Characterization of the necrotic protein that regulates the Toll-mediated immune response in Drosophila. Robertson, A.S., Belorgey, D., Lilley, K.S., Lomas, D.A., Gubb, D., Dafforn, T.R. J. Biol. Chem. (2003) [Pubmed]
  4. Comparative analysis of serine protease-related genes in the honey bee genome: possible involvement in embryonic development and innate immunity. Zou, Z., Lopez, D.L., Kanost, M.R., Evans, J.D., Jiang, H. Insect Mol. Biol. (2006) [Pubmed]
  5. Activation of Drosophila Toll during fungal infection by a blood serine protease. Ligoxygakis, P., Pelte, N., Hoffmann, J.A., Reichhart, J.M. Science (2002) [Pubmed]
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