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Chemical Compound Review

ALUMINUM     aluminum

Synonyms: aluminio, Aluminium, Metana, Adom, C-Pigment 1, ...
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Disease relevance of aluminum


Psychiatry related information on aluminum

  • Controversy exists over whether aluminium has a role in the aetiology of Alzheimer's disease [6].
  • Its application had a beneficial effect on 7 of 9 patients previously exposed to dialysate prepared from water with a high aluminium content and prevented the appearance of dementia in 24 patients whose water was so treated from the start of haemodialysis [7].
  • The difference between the visual evoked potentials stimulated by flash and pattern was significantly greater in the patients than in the controls (31.6 [4.3] vs 19.4 [2.4] ms) and was significantly related to the symbol digit coding response times and to the oral aluminium intake [8].
  • Furthermore, elevated aluminium content in multiple cortical regions was not found in 2 vascular dementias of the elderly [9].
  • The aetiology of these changes may be genetic = (related to chromosoma 21), toxic (aluminium) or infective (slow agents similar to those that cause Creutzfeldt-Jakob disease, kuru and scrapie) [10].

High impact information on aluminum


Chemical compound and disease context of aluminum


Biological context of aluminum


Anatomical context of aluminum


Associations of aluminum with other chemical compounds


Gene context of aluminum


Analytical, diagnostic and therapeutic context of aluminum


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  2. Does silicon protect against aluminium toxicity in dialysis patients? Fahal, I.H., Yaqoob, M., Williams, P.S., Ahmad, R., Roberts, N.B., Bell, G.M. Lancet (1994) [Pubmed]
  3. Hypercalcaemic osteomalacia due to aluminium toxicity. Boyce, B.F., Fell, G.S., Elder, H.Y., Junor, B.J., Elliot, H.L., Beastall, G., Fogelman, I., Boyle, I.T. Lancet (1982) [Pubmed]
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  5. Aluminium-related bone disease and haemodialysis. Seyfert, U.T., Didion, K., Albert, F.W. Lancet (1987) [Pubmed]
  6. Absence of aluminium in neuritic plaque cores in Alzheimer's disease. Landsberg, J.P., McDonald, B., Watt, F. Nature (1992) [Pubmed]
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  11. GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4. Sondek, J., Lambright, D.G., Noel, J.P., Hamm, H.E., Sigler, P.B. Nature (1994) [Pubmed]
  12. Plasminogen-activator-inhibitor-1 4G/5G promoter polymorphism and prognosis of severely injured patients. Menges, T., Hermans, P.W., Little, S.G., Langefeld, T., Böning, O., Engel, J., Sluijter, M., de Groot, R., Hempelmann, G. Lancet (2001) [Pubmed]
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  14. Aluminium and dementia. Davenport, A., Goodall, R. Lancet (1992) [Pubmed]
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  16. GTPgammaS-induced actin polymerisation in vitro: ATP- and phosphoinositide-independent signalling via Rho-family proteins and a plasma membrane-associated guanine nucleotide exchange factor. Katanaev, V.L., Wymann, M.P. J. Cell. Sci. (1998) [Pubmed]
  17. Absence of skin sensitivity to oxides of aluminium, silicon, titanium or zirconium in patients with Crohn's disease. Lee, J.C., Halpern, S., Lowe, D.G., Forbes, A., Lennard-Jones, J.E. Gut (1996) [Pubmed]
  18. Aluminium inhibits muscarinic agonist-induced inositol 1,4,5-trisphosphate production and calcium mobilization in permeabilized SH-SY5Y human neuroblastoma cells. Wood, P.C., Wojcikiewicz, R.J., Burgess, J., Castleden, C.M., Nahorski, S.R. J. Neurochem. (1994) [Pubmed]
  19. Gallium-67 as a potential marker for aluminium transport in rat brain: implications for Alzheimer's disease. Pullen, R.G., Candy, J.M., Morris, C.M., Taylor, G., Keith, A.B., Edwardson, J.A. J. Neurochem. (1990) [Pubmed]
  20. Aluminium deposition in bone after contamination of drinking water supply. Eastwood, J.B., Levin, G.E., Pazianas, M., Taylor, A.P., Denton, J., Freemont, A.J. Lancet (1990) [Pubmed]
  21. Kinetics of serum and urinary aluminium after renal transplantation. Boukari, M., Jaudon, M.C., Rottembourg, P.F., Luciani, J., Legrain, M., Galli, A. Lancet (1978) [Pubmed]
  22. Aluminium, hot water tanks, and neurobiology. Brenner, S. Lancet (1989) [Pubmed]
  23. Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation. Steffen, A., Rottner, K., Ehinger, J., Innocenti, M., Scita, G., Wehland, J., Stradal, T.E. EMBO J. (2004) [Pubmed]
  24. Toxic effects of aluminium on nerve cells and synaptic transmission. Meiri, H., Banin, E., Roll, M., Rousseau, A. Prog. Neurobiol. (1993) [Pubmed]
  25. Erythropoietin, aluminium, and anaemia in patients on haemodialysis. Rosenlöf, K., Fyhrquist, F., Tenhunen, R. Lancet (1990) [Pubmed]
  26. Uptake of aluminium into central nervous system along nasal-olfactory pathways. Perl, D.P., Good, P.F. Lancet (1987) [Pubmed]
  27. Aluminium increases permeability of the blood-brain barrier to labelled DSIP and beta-endorphin: possible implications for senile and dialysis dementia. Banks, W.A., Kastin, A.J. Lancet (1983) [Pubmed]
  28. Aluminium and the nucleus of nerve cells. Lukiw, W.J., Kruck, T.P., Crapper McLachlan, D.R. Lancet (1989) [Pubmed]
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  33. Association of PAP-1 and Prp3p, the products of causative genes of dominant retinitis pigmentosa, in the tri-snRNP complex. Maita, H., Kitaura, H., Ariga, H., Iguchi-Ariga, S.M. Exp. Cell Res. (2005) [Pubmed]
  34. PAP-1, the mutated gene underlying the RP9 form of dominant retinitis pigmentosa, is a splicing factor. Maita, H., Kitaura, H., Keen, T.J., Inglehearn, C.F., Ariga, H., Iguchi-Ariga, S.M. Exp. Cell Res. (2004) [Pubmed]
  35. CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing. Maita, H., Kitaura, H., Ariga, H., Iguchi-Ariga, S.M. Exp. Cell Res. (2005) [Pubmed]
  36. Interferon-gamma inductive effect of liposomes as an immunoadjuvant. Aramaki, Y., Suda, H., Tsuchiya, S. Vaccine (1995) [Pubmed]
  37. Alzheimer's-disease-like changes in tau protein processing: association with aluminium accumulation in brains of renal dialysis patients. Harrington, C.R., Wischik, C.M., McArthur, F.K., Taylor, G.A., Edwardson, J.A., Candy, J.M. Lancet (1994) [Pubmed]
  38. Acute aluminium intoxication in patients on continuous ambulatory peritoneal dialysis. Cumming, A.D., Simpson, G., Bell, D., Cowie, J., Winney, R.J. Lancet (1982) [Pubmed]
  39. Improvement in the erythropoiesis of chronic haemodialysis patients with desferrioxamine. de la Serna, F.J., Praga, M., Gilsanz, F., Rodicio, J.L., Ruilope, L.M., Alcazar, J.M. Lancet (1988) [Pubmed]
  40. Serum aluminium levels in patients on peritoneal dialysis. Gilli, P., Farinelli, A., Fagioli, F., De Bastiani, P., Buoncristiani, U. Lancet (1980) [Pubmed]
  41. Brain-aluminium concentration in dialysis encephalopathy. McDermott, J.R., Smith, A.I., Ward, M.K., Parkinson, I.S., Kerr, D.N. Lancet (1978) [Pubmed]
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