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Gene Review

glnA  -  glutamine synthetase

Bacteroides fragilis NCTC 9343

 
 
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Disease relevance of glnA

 

High impact information on glnA

  • The 687-bp sequences analysed for the glnA gene showed 112 nucleotide substitutions, 96 of which separated the population into the same two divisions as those described for recA [1].
  • Thus, it appears that the evolution of recA and glnA genes is similar to that of the whole chromosome of B. fragilis [1].
  • A single mRNA transcription start point was identified upstream of the B. fragilis glnA open reading frame [2].
  • The nucleotide sequence of a 2777 bp DNA segment containing the Bacteroides fragilis glnA gene was determined [2].
 

Analytical, diagnostic and therapeutic context of glnA

  • The apparent Mr of the GS subunit determined by SDS-PAGE was approximately 75,000 [2].

References

  1. RecA and glnA sequences separate the bacteroides fragilis population into two genetic divisions associated with the antibiotic resistance genotypes cepA and cfiA. Gutacker, M., Valsangiacomo, C., Bernasconi, M.V., Piffaretti, J.C. J. Med. Microbiol. (2002) [Pubmed]
  2. Molecular analysis of a novel glutamine synthetase of the anaerobe Bacteroides fragilis. Hill, R.T., Parker, J.R., Goodman, H.J., Jones, D.T., Woods, D.R. J. Gen. Microbiol. (1989) [Pubmed]
 
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