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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

gp43  -  DNA polymerase

Prochlorococcus phage P-SSM4

 
 
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Disease relevance of 43

  • However, gp43 from phage RB69, a phylogenetic relative of T4, was crystallized and its structure solved in a complex with single-stranded DNA occupying the Exo site, as well as in the unliganded form [1].
  • We also contrast the properties of the T4 DNA replication complex to the functionally analogous complexes of other organisms, particularly Escherichia coli, and point out some of the unanswered questions about gp43 and T4 DNA replication [1].
 

High impact information on 43

  • In contrast to gp43, several loops in the exonuclease and thumb domains are more closely packed; this apparently blocks primer binding to the exonuclease active site [2].
  • This protein (gp43), the product of gene 43, binds to a segment of its mRNA that overlaps its ribosome binding site, and thereby blocks translation [3].
  • We present data that show that the replicative and autoregulatory functions are mutually exclusive activities of this polymerase, and suggest a model for gp43 synthesis that links autoregulation to replicative demand [3].
 

Biological context of 43

  • The minimum operator sequence to which gp43 binds consists of 36 nucleotides that include a hairpin (containing a 5 base-pair helix and an 8 nucleotide loop) and a single-stranded segment that contains the Shine-Dalgarno sequence of the ribosome binding site [3].

References

  1. DNA polymerase of the T4-related bacteriophages. Karam, J.D., Konigsberg, W.H. Prog. Nucleic Acid Res. Mol. Biol. (2000) [Pubmed]
  2. Crystal structure of a thermostable type B DNA polymerase from Thermococcus gorgonarius. Hopfner, K.P., Eichinger, A., Engh, R.A., Laue, F., Ankenbauer, W., Huber, R., Angerer, B. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  3. Autogenous translational operator recognized by bacteriophage T4 DNA polymerase. Tuerk, C., Eddy, S., Parma, D., Gold, L. J. Mol. Biol. (1990) [Pubmed]
 
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