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Gene Review: 

AP-1-2beta  -  Adaptor Protein complex 1/2, beta subunit

Drosophila melanogaster

Synonyms: AP-1/2beta, AP-1beta1, AP-2beta, AP-beta1, AP1beta1, ...
 
 
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High impact information on Bap

  • Additional diversification of AP complexes arises from the existence of adaptin isoforms encoded by distinct genes or resulting from alternative splicing of mRNAs [1].
  • The AP-2 family of transcription factors (AP-2alpha, AP-2beta and AP-2gamma) is temporally and spatially regulated in mammals and has also been implicated in oncogenesis [2].
  • The differential interaction of beta with alpha-adaptin and beta' with gamma-adaptin in mammalian cells is likely to depend on the few non-conservative differences between their respective sequences and BAD1 [3].
  • To test its functional characteristics, a 'myc'-tagged version of BAD1 was expressed in Cos cells [3].
 

Anatomical context of Bap

References

  1. Adaptins: the final recount. Boehm, M., Bonifacino, J.S. Mol. Biol. Cell (2001) [Pubmed]
  2. Cloning and characterization of the Drosophila homologue of the AP-2 transcription factor. Bauer, R., McGuffin, M.E., Mattox, W., Tainsky, M.A. Oncogene (1998) [Pubmed]
  3. Cloning of Drosophila beta-adaptin and its localization on expression in mammalian cells. Camidge, D.R., Pearse, B.M. J. Cell. Sci. (1994) [Pubmed]
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