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Gene Review

AP-2alpha  -  Adaptor Protein complex 2, alpha subunit

Drosophila melanogaster

Synonyms: AP-2, AP-2 complex subunit alpha, AP2, Alpha-Adaptin, Alpha-adaptin, ...
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High impact information on alpha-Adaptin

  • Rapid flow of information in the nervous system involves presynaptic vesicle recycling by clathrin-mediated endocytosis, an event triggered by the alpha-adaptin-containing AP2 complex [1].
  • Our results suggest an alpha-adaptin-dependent control of the vesicle cycle that maintains the balance between the amount of vesicle- and surface-associated membranes [1].
  • Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet [2].
  • They contain distinct binding motifs for alpha-adaptin (alpha-Ada) and proteins with Eps15 homology (EH) domains, which regulate endocytosis, and for E3 ubiquitin ligases, which target proteins for proteasome-mediated degradation [3].
  • Specifically, we show that alpha-adaptin and Rab11, which function critically in the endocytic pathways of all previously examined animal cells, are localized to neighboring compartments at the posterior pole of stage 8-10 oocytes [4].

Biological context of alpha-Adaptin


Anatomical context of alpha-Adaptin


Associations of alpha-Adaptin with chemical compounds

  • Nifurtimox, compound ada and compound 1B were clearly mutagenic and recombinogenic whereas the remaining six compounds were negative [10].

Physical interactions of alpha-Adaptin


Other interactions of alpha-Adaptin

  • Sanpodo endocytosis requires alpha-Adaptin, a Numb-binding partner involved in clathrin-mediated endocytosis [5].
  • Our results establish numb- and alpha-adaptin-dependent endocytosis of Sanpodo as the mechanism by which Notch is regulated during external sensory organ development [5].
  • Epsin consists of an epsin NH(2)-terminal homology (ENTH) domain that promotes the interaction with phospholipids, several AP2 binding sites, two clathrin binding sequences, and several Eps15 homology (EH) domain binding motifs [11].
  • The expression patterns of dynamin, detected in the embryo by in situ hybridization methods, are very similar to those reported here for alpha-adaptin reflecting the likely coordinated expression of endocytic components [7].
  • The differential interaction of beta with alpha-adaptin and beta' with gamma-adaptin in mammalian cells is likely to depend on the few non-conservative differences between their respective sequences and BAD1 [9].


  1. Role of Drosophila alpha-adaptin in presynaptic vesicle recycling. González-Gaitán, M., Jäckle, H. Cell (1997) [Pubmed]
  2. Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet. Ooi, C.E., Moreira, J.E., Dell'Angelica, E.C., Poy, G., Wassarman, D.A., Bonifacino, J.S. EMBO J. (1997) [Pubmed]
  3. Numb proteins specify asymmetric cell fates via an endocytosis- and proteasome-independent pathway. Tang, H., Rompani, S.B., Atkins, J.B., Zhou, Y., Osterwalder, T., Zhong, W. Mol. Cell. Biol. (2005) [Pubmed]
  4. Rab11 polarization of the Drosophila oocyte: a novel link between membrane trafficking, microtubule organization, and oskar mRNA localization and translation. Dollar, G., Struckhoff, E., Michaud, J., Cohen, R.S. Development (2002) [Pubmed]
  5. Numb and alpha-Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs. Hutterer, A., Knoblich, J.A. EMBO Rep. (2005) [Pubmed]
  6. The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila. Berdnik, D., Török, T., González-Gaitán, M., Knoblich, J.A. Dev. Cell (2002) [Pubmed]
  7. Alpha-adaptin, a marker for endocytosis, is expressed in complex patterns during Drosophila development. Dornan, S., Jackson, A.P., Gay, N.J. Mol. Biol. Cell (1997) [Pubmed]
  8. Drosophila homologue of Eps15 is essential for synaptic vesicle recycling. Majumdar, A., Ramagiri, S., Rikhy, R. Exp. Cell Res. (2006) [Pubmed]
  9. Cloning of Drosophila beta-adaptin and its localization on expression in mammalian cells. Camidge, D.R., Pearse, B.M. J. Cell. Sci. (1994) [Pubmed]
  10. Genotoxicity testing of antiparasitic nitrofurans in the Drosophila wing somatic mutation and recombination test. Moraga, A.A., Graf, U. Mutagenesis (1989) [Pubmed]
  11. The ubiquitin-interacting motifs target the endocytic adaptor protein epsin for ubiquitination. Oldham, C.E., Mohney, R.P., Miller, S.L., Hanes, R.N., O'Bryan, J.P. Curr. Biol. (2002) [Pubmed]
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