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Gene Review

AP1B1  -  adaptor-related protein complex 1, beta 1...

Homo sapiens

Synonyms: ADTB1, AP-1 complex subunit beta-1, AP105A, Adaptor protein complex AP-1 subunit beta-1, Adaptor-related protein complex 1 subunit beta-1, ...
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Disease relevance of AP1B1


High impact information on AP1B1

  • This suggests that the phosphorylation of arrestin-3 does not directly regulate interaction with endocytic (clathrin, beta-adaptin) or signaling (Src) components and is in contrast to arrestin-2, where phosphorylation appears to regulate interaction with clathrin and Src [2].
  • The observation that BAM22 inhibited the Leu-enkephalin-promoted cAMP inhibition in rat dorsal root ganglia neurons supports the potential physiological implication of such regulatory mechanism [3].
  • Structure of the promoter and genomic organization of the human beta'-adaptin gene (BAM22) from chromosome 22q12 [4].
  • As part of the genomic characterization of the BAM22 locus, we sequenced 40 kb covering exons 1-4 and 12 kb upstream from the start of gene transcription [4].
  • The genomic sequencing of a 40-kb region bounded by the EWS and BAM22 genes and containing a CpG-rich region has identified two new genes in the q12 region of chromosome 22 [5].

Biological context of AP1B1


Anatomical context of AP1B1


Associations of AP1B1 with chemical compounds

  • The distributions of the immunoreactive labeling for LENK, MENK, MERF, BAM22P, and PEPE were indistinguishable, and double-label studies showed that LENK, MERF, and BAM22P were colocalized within individual neurons and fibers [8].
  • Antisera against several enkephalin peptides were used: leucine-enkephalin (LENK), methionine-enkephalin (MENK), methionine-enkephalin-arg6-phe7 (MERF), methionine-enkephalin-arg6-gly7-leu8 (MERGL), Peptide E (PEPE), and BAM22P [8].
  • Substantial cross-reactivity is seen with some other naturally occurring opioid peptides bearing the enkephalin sequence, such as dynorphin, alpha-neo-endorphin and BAM 22, but cross-reactivity is lacking in the case of certain synthetic enkephalin derivatives possessing a D-amino acid in position 2 [10].
  • Peroxidase-catalyzed oxidation of 3,3 ,5,5 -tetramethylbenzidine (TMB) was inhibited by o-aminophenol (AP), 2-amino-4-tert-butylphenol (ATBP), 2-amino-4,6-di-tert-butylphenol (ADTBP), and 4-tert-butylpyrocatechol (TBP) [11].
  • 3. Endopeptidase H2 hydrolyzes the Phe-Ser bond of peptides related to bradykinin and its activity appears to be limited to peptide chains of < or = 18 amino acid residues since it does not hydrolyze BAM 22, peptide E or kininogen [12].

Analytical, diagnostic and therapeutic context of AP1B1

  • Under these conditions, RT-PCR assays show that beta-adaptin mRNA is normally synthesized, reason why protein translation or protein structure of beta-adaptin might be altered [6].


  1. Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene. Peyrard, M., Fransson, I., Xie, Y.G., Han, F.Y., Ruttledge, M.H., Swahn, S., Collins, J.E., Dunham, I., Collins, V.P., Dumanski, J.P. Hum. Mol. Genet. (1994) [Pubmed]
  2. Regulation of arrestin-3 phosphorylation by casein kinase II. Kim, Y.M., Barak, L.S., Caron, M.G., Benovic, J.L. J. Biol. Chem. (2002) [Pubmed]
  3. Simultaneous activation of the delta opioid receptor (deltaOR)/sensory neuron-specific receptor-4 (SNSR-4) hetero-oligomer by the mixed bivalent agonist bovine adrenal medulla peptide 22 activates SNSR-4 but inhibits deltaOR signaling. Breit, A., Gagnidze, K., Devi, L.A., Lagacé, M., Bouvier, M. Mol. Pharmacol. (2006) [Pubmed]
  4. Structure of the promoter and genomic organization of the human beta'-adaptin gene (BAM22) from chromosome 22q12. Peyrard, M., Pan, H.Q., Kedra, D., Fransson, I., Swahn, S., Hartman, K., Clifton, S.W., Roe, B.A., Dumanski, J.P. Genomics (1996) [Pubmed]
  5. Identification of new members of the Gas2 and Ras families in the 22q12 chromosome region. Zucman-Rossi, J., Legoix, P., Thomas, G. Genomics (1996) [Pubmed]
  6. beta-adaptin: Key molecule for microglial scavenger receptor function under oxidative stress. Manzano-Le??n, N., Delgado-Coello, B., Guaderrama-D??az, M., Mas-Oliva, J. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  7. Characterization of the mouse beta-prime adaptin gene; cDNA sequence, genomic structure, and chromosomal localization. Guilbaud, C., Peyrard, M., Fransson, I., Clifton, S.W., Roe, B.A., Carter, N.P., Dumanski, J.P. Mamm. Genome (1997) [Pubmed]
  8. The distribution of proenkephalin-derived peptides in the central nervous system of turtles. Reiner, A. J. Comp. Neurol. (1987) [Pubmed]
  9. Screening of adrenal medullary neuropeptides for putative neurotrophic effects. Unsicker, K., Stögbauer, F. Int. J. Dev. Neurosci. (1992) [Pubmed]
  10. Characteristics of a monoclonal beta-endorphin antibody recognizing the N-terminus of opioid peptides. Herz, A., Gramsch, C., Höllt, V., Meo, T., Riethmüller, G. Life Sci. (1982) [Pubmed]
  11. Inhibition of peroxidase-catalyzed oxidation of 3,3 ,5,5 -tetramethylbenzidine by aminophenols. Naumchik, I.V., Karasyova, E.I., Metelitza, D.I., Edimecheva, I.P., Sorokin, V.L., Shadyro, O.I. Biochemistry Mosc. (2005) [Pubmed]
  12. Purification and characterization of endopeptidase H2, a kinin inactivating serine proteinase (kininase) from human urine. Casarini, D.E., Stella, R.C., Araújo, M.S., Sampaio, C.A. Braz. J. Med. Biol. Res. (1993) [Pubmed]
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