High impact information on Ctxn1

• In situ hybridization studies detect cortexin mRNA primarily in neurons of rodent cerebral cortex, but not in cells of the hindbrain or white matter regions [1].
• The amino acid sequence of rat cortexin and its mouse homologue are nearly identical (98% similarity), and both contain a conserved single membrane-spanning region in the middle of each sequence [1].
• Based upon these observations, we conclude that Ctxn is not involved in the genetic defects found in nr, tg or mnd mice [2].
• Probable exclusion of the cortexin-encoding gene as a candidate for mouse neurological mutants: nervous, tottering and motor neuron degeneration [2].

Anatomical context of Ctxn1

• Identification of cortexin: a novel, neuron-specific, 82-residue membrane protein enriched in rodent cerebral cortex [1].

Analytical, diagnostic and therapeutic context of Ctxn1

• Northern blot analysis shows that cortexin mRNA is brain-specific, cortex-enriched, and present at significant levels in fetal brain, with peak expression in postnatal rodent brain [1].

References