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S6kII  -  Ribosomal protein S6 kinase II

Drosophila melanogaster

Synonyms: CG17596, Dmel\CG17596, RSK, Rsk, S6KII, ...
 
 
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Psychiatry related information on S6kII

 

High impact information on S6kII

  • Consistent with these physiological phenotypes, RSK negatively regulated ERK-mediated developmental processes and gene expressions by blocking the nuclear localization of ERK in a kinase activity-independent manner [2].
  • Furthermore, dPDK1 genetically interacts with dRSK but not with dPKN, encoding two substrates of PDK1 in vitro [3].
  • The conceptually translated protein is 60-63% identical to vertebrate RSK homologs and contains a perfectly conserved mitogen-activated protein kinase phosphorylation site [4].
  • The behavioral defects in the pavlovian task can be rescued by the genomic S6KII transgene [1].
 

Other interactions of S6kII

  • Thus, the results suggest that dPDK1 is required for dRSK but not dPKN activation and that it regulates insulin-mediated growth through two main effector branches, dAkt and dS6K [3].

References

  1. The S6KII (rsk) gene of Drosophila melanogaster differentially affects an operant and a classical learning task. Putz, G., Bertolucci, F., Raabe, T., Zars, T., Heisenberg, M. J. Neurosci. (2004) [Pubmed]
  2. Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development. Kim, M., Lee, J.H., Koh, H., Lee, S.Y., Jang, C., Chung, C.J., Sung, J.H., Blenis, J., Chung, J. EMBO J. (2006) [Pubmed]
  3. PDK1 regulates growth through Akt and S6K in Drosophila. Rintelen, F., Stocker, H., Thomas, G., Hafen, E. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  4. The Drosophila melanogaster ribosomal S6 kinase II-encoding sequence. Wassarman, D.A., Solomon, N.M., Rubin, G.M. Gene (1994) [Pubmed]
 
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