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MeSH Review

Conditioning, Operant

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Psychiatry related information on Conditioning, Operant


High impact information on Conditioning, Operant


Chemical compound and disease context of Conditioning, Operant

  • These results suggest that neonatal ventral hippocampal lesions facilitate instrumental learning for both natural and drug rewards, and reduce inhibitory control over cocaine taking while promoting cocaine seeking and relapse after withdrawal [10].
  • Rats were trained to discriminate the effects of nicotine in a standard, two-bar operant conditioning procedure with food reinforcement [11].
  • In addition, rats that received saline immediately prior to repeated alcohol deprivation sessions self-administered ethanol at increasing levels that were above those achieved in the last operant-conditioning session prior to the initial 2-week deprivation period [12].
  • Male Fisher rats were trained under a 5-response, fixed-ratio schedule of stimulus-shock termination or a 10-response, fixed-ratio schedule of food-presentation to discriminate between d-amphetamine (1.0 mg/kg i.p.) and saline in a two-lever, operant conditioning procedure [13].
  • EEG operant conditioning in an alumina-gel monkey model (N = 14) to decrease EMG, to increase 9 Hz or decrease 9 Hz, and to increase 23 Hz (18 Hz and 26 Hz in 2 pilot monkeys), respectively, was not consistently beneficial in reducing seizures [14].

Biological context of Conditioning, Operant


Anatomical context of Conditioning, Operant


Gene context of Conditioning, Operant

  • To this end, male cannabinoid CB1 receptor deficient mice (CB1R-/-) and their wild-type littermate controls (CB1R+/+) were trained in an appetitively-motivated operant conditioning task, in which food-deprived animals received a food reward on nose-poking into an illuminated hole [24].
  • This difference in behavior is not explained by an anosmic condition as there were no differences between V1bR-/- and V1bR+/+ mice in their abilities to detect a cookie buried in clean bedding, or in their ability to perform in an operant conditioning task using a fully automated liquid dilution olfactometer [25].
  • A conceptual model of operant conditioning and the levels at which rutabaga and white influence conditioning is proposed [26].
  • These data provide novel evidence for NMDA receptor-dependent plasticity within corticostriatal networks in the acquisition of appetitive instrumental learning [27].
  • N-methyl-D-aspartate receptor-dependent plasticity within a distributed corticostriatal network mediates appetitive instrumental learning [27].

Analytical, diagnostic and therapeutic context of Conditioning, Operant


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  2. Phenobarbitone and the relationship between extraversion and reinforcement in verbal operant conditioning. Gupta, U. British journal of psychology (London, England : 1953) (1984) [Pubmed]
  3. Behavior modification as a therapeutic technique for use with parents of emotionally disturbed children in residential treatment. Goodman, E.O. Child psychiatry and human development. (1975) [Pubmed]
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  5. Extinction of cocaine self-administration reveals functionally and temporally distinct dopaminergic signals in the nucleus accumbens. Stuber, G.D., Wightman, R.M., Carelli, R.M. Neuron (2005) [Pubmed]
  6. Memory and addiction: shared neural circuitry and molecular mechanisms. Kelley, A.E. Neuron (2004) [Pubmed]
  7. Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice. Kelliher, K.R., Ziesmann, J., Munger, S.D., Reed, R.R., Zufall, F. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  8. Atherosclerosis-related responses to cigarette smoking in the baboon. Rogers, W.R., Bass, R.L., Johnson, D.E., Kruski, A.W., McMahan, C.A., Montiel, M.M., Mott, G.E., Wilbur, R.L., McGill, H.C. Circulation (1980) [Pubmed]
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  10. Motivational responses to natural and drug rewards in rats with neonatal ventral hippocampal lesions: an animal model of dual diagnosis schizophrenia. Chambers, R.A., Self, D.W. Neuropsychopharmacology (2002) [Pubmed]
  11. Nicotine cue in rats analysed with drugs acting on cholinergic and 5-hydroxytryptamine mechanisms. Stolerman, I.P., Pratt, J.A., Garcha, H.S., Giardini, V., Kumar, R. Neuropharmacology (1983) [Pubmed]
  12. The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats. Schroeder, J.P., Overstreet, D.H., Hodge, C.W. Psychopharmacology (Berl.) (2005) [Pubmed]
  13. Evaluation of the stereoisomers of deprenyl for amphetamine-like discriminative stimulus effects in rats. Yasar, S., Schindler, C.W., Thorndike, E.B., Szelenyi, I., Goldberg, S.R. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  14. EEG operant conditioning in a monkey model: I. Seizure data. Lockard, J.S., Wyler, A.R., Finch, C.A., Hurlburt, K.E. Epilepsia (1977) [Pubmed]
  15. Stimulus processing of glycine is dissociable from that of sucrose and glucose based on behaviorally measured taste signal detection in Sac 'taster' and 'non-taster' mice. Eylam, S., Spector, A.C. Chem. Senses (2004) [Pubmed]
  16. Plasma lactate levels during baseline and blood pressure conditioning in the baboon. Harris, A.H., Turkkan, J.S. Physiol. Behav. (1982) [Pubmed]
  17. Comparison of neurokinin substance P with morphine in effects on food-reinforced operant behavior and feeding. Hasenöhrl, R.U., Schwarting, R.K., Gerhardt, P., Privou, C., Huston, J.P. Physiol. Behav. (1994) [Pubmed]
  18. Effects of inhaled nicotine on instrumental learning of blood pressure responses. Birbaumer, N., Elbert, T., Rockstroh, B., Krämer, J., Lutzenberger, W., Grossmann, P. Biofeedback and self-regulation. (1992) [Pubmed]
  19. Reduction and replacement of laboratory animals in toxicological testing and research. Interim report 1984-1987. Zbinden, G. Biomed. Environ. Sci. (1988) [Pubmed]
  20. Functional Interaction Between NMDA and mGlu5 Receptors: Effects on Working Memory, Instrumental Learning, Motor Behaviors, and Dopamine Release. Homayoun, H., Stefani, M.R., Adams, B.W., Tamagan, G.D., Moghaddam, B. Neuropsychopharmacology (2004) [Pubmed]
  21. Involvement of NMDA and AMPA/KA receptors in the nucleus accumbens core in instrumental learning guided by reward-predictive cues. Giertler, C., Bohn, I., Hauber, W. Eur. J. Neurosci. (2005) [Pubmed]
  22. Fos expression and task-related neuronal activity in rat cerebral cortex after instrumental learning. Svarnik, O.E., Alexandrov, Y.I., Gavrilov, V.V., Grinchenko, Y.V., Anokhin, K.V. Neuroscience (2005) [Pubmed]
  23. Enhanced odor discrimination and impaired olfactory memory by spatially controlled switch of AMPA receptors. Shimshek, D.R., Bus, T., Kim, J., Mihaljevic, A., Mack, V., Seeburg, P.H., Sprengel, R., Schaefer, A.T. PLoS Biol. (2005) [Pubmed]
  24. Cannabinoid CB1 receptor is dispensable for memory extinction in an appetitively-motivated learning task. Hölter, S.M., Kallnik, M., Wurst, W., Marsicano, G., Lutz, B., Wotjak, C.T. Eur. J. Pharmacol. (2005) [Pubmed]
  25. Social motivation is reduced in vasopressin 1b receptor null mice despite normal performance in an olfactory discrimination task. Wersinger, S.R., Kelliher, K.R., Zufall, F., Lolait, S.J., O'Carroll, A.M., Young, W.S. Hormones and behavior. (2004) [Pubmed]
  26. Genetic dissociation of acquisition and memory strength in the heat-box spatial learning paradigm in Drosophila. Diegelmann, S., Zars, M., Zars, T. Learn. Mem. (2006) [Pubmed]
  27. N-methyl-D-aspartate receptor-dependent plasticity within a distributed corticostriatal network mediates appetitive instrumental learning. Baldwin, A.E., Holahan, M.R., Sadeghian, K., Kelley, A.E. Behav. Neurosci. (2000) [Pubmed]
  28. A simple procedure for assessing ataxia in rats: effects of phencyclidine. Melnick, S.M., Rodriguez, J.S., Bernardi, R.E., Ettenberg, A. Pharmacol. Biochem. Behav. (2002) [Pubmed]
  29. Ethanol self-administration in ALKO rats: I. Effects of selection and concentration. Ritz, M.C., George, F.R., Meisch, R.A. Alcohol (1989) [Pubmed]
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