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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Serpina7  -  serine (or cysteine) peptidase inhibitor,...

Mus musculus

Synonyms: C730040N12Rik, Serpin A7, T4-binding globulin, Tbg, Thyroxine-binding globulin
 
 
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High impact information on Serpina7

  • It was therefore best to give the melarsoprol towards the end of the DFMO regimen, and as a guanylhydrazone (TBG) also blocks trypanothione (polyamine) biosynthesis, if TBG/DFMO are given together the treatment period can be reduced to 8 days [1].
  • The efficacy of 1,3,5-triacetylbenzene tris(guanylhydrazone) trihydrochloride i.e. [(TBG)] in the treatment of early and late stage infections of Trypanosoma brucei in mice was investigated [2].
  • If treatment was delayed to 21 days after infection then the mice had to be given either suramin (1 X 20 mg kg-1) or difluoromethyl-ornithine (DFMO) 2% solution for 14 days in addition to either 15 mg kg-1 (TBG) daily for 4 days or 10 mg kg-1 twice daily for 4 days to obtain permanent cures [2].

References

  1. The potentiation of arsenicals with difluoromethylornithine (DFMO): experimental studies in murine trypanosomiasis. Jennings, F.W. Bulletin de la Société de pathologie exotique et de ses filiales. (1988) [Pubmed]
  2. Chemotherapy of trypanosomiasis: the use of guanylhydrazone compounds in the treatment of experimental murine trypanosomiasis. Jennings, F.W., Ulrich, P., Cerami, A. Trop. Med. Parasitol. (1987) [Pubmed]
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