Chemical Compound Review:
AC1L1AU5 2-amino-4-[[1-[3-[4-[2-[[2- [(4-amino-4...
Synonyms:
- Engineering the substrate specificity of glutathione reductase toward that of trypanothione reduction. Henderson, G.B., Murgolo, N.J., Kuriyan, J., Osapay, K., Kominos, D., Berry, A., Scrutton, N.S., Hinchliffe, N.W., Perham, R.N., Cerami, A. Proc. Natl. Acad. Sci. U.S.A. (1991)
- "Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease. Henderson, G.B., Ulrich, P., Fairlamb, A.H., Rosenberg, I., Pereira, M., Sela, M., Cerami, A. Proc. Natl. Acad. Sci. U.S.A. (1988)
- Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs. Chan, C., Yin, H., Garforth, J., McKie, J.H., Jaouhari, R., Speers, P., Douglas, K.T., Rock, P.J., Yardley, V., Croft, S.L., Fairlamb, A.H. J. Med. Chem. (1998)
- The parasite-specific trypanothione metabolism of trypanosoma and leishmania. Krauth-Siegel, R.L., Meiering, S.K., Schmidt, H. Biol. Chem. (2003)
- Rational drug design using trypanothione reductase as a target for anti-trypanosomal and anti-leishmanial drug leads. Austin, S.E., Khan, M.O., Douglas, K.T. Drug design and discovery. (1999)
- Aldehyde and phosphinate analogs of glutathione and glutathionylspermidine: potent, selective binding inhibitors of the E. coli bifunctional glutathionylspermidine synthetase/amidase. Lin, C.H., Chen, S., Kwon, D.S., Coward, J.K., Walsh, C.T. Chem. Biol. (1997)
- Molecular mechanisms and therapeutic approaches to the treatment of African trypanosomiasis. Wang, C.C. Annu. Rev. Pharmacol. Toxicol. (1995)
- Molecular studies on trypanothione reductase, a target for antiparasitic drugs. Walsh, C., Bradley, M., Nadeau, K. Trends Biochem. Sci. (1991)
- Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase. Pai, C.H., Chiang, B.Y., Ko, T.P., Chou, C.C., Chong, C.M., Yen, F.J., Chen, S., Coward, J.K., Wang, A.H., Lin, C.H. EMBO J. (2006)
- Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages. Dumas, C., Ouellette, M., Tovar, J., Cunningham, M.L., Fairlamb, A.H., Tamar, S., Olivier, M., Papadopoulou, B. EMBO J. (1997)
- A trypanothione-dependent glyoxalase I with a prokaryotic ancestry in Leishmania major. Vickers, T.J., Greig, N., Fairlamb, A.H. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Glutathionylspermidine metabolism in Escherichia coli. Smith, K., Borges, A., Ariyanayagam, M.R., Fairlamb, A.H. Biochem. J. (1995)
- Metabolism and functions of trypanothione in the Kinetoplastida. Fairlamb, A.H., Cerami, A. Annu. Rev. Microbiol. (1992)
- X-ray structure of trypanothione reductase from Crithidia fasciculata at 2.4-A resolution. Kuriyan, J., Kong, X.P., Krishna, T.S., Sweet, R.M., Murgolo, N.J., Field, H., Cerami, A., Henderson, G.B. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania. Mukhopadhyay, R., Dey, S., Xu, N., Gage, D., Lightbody, J., Ouellette, M., Rosen, B.P. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Glutathionylspermidine metabolism in Escherichia coli. Purification, cloning, overproduction, and characterization of a bifunctional glutathionylspermidine synthetase/amidase. Bollinger, J.M., Kwon, D.S., Huisman, G.W., Kolter, R., Walsh, C.T. J. Biol. Chem. (1995)
- Trypanosoma brucei and Trypanosoma cruzi tryparedoxin peroxidases catalytically detoxify peroxynitrite via oxidation of fast reacting thiols. Trujillo, M., Budde, H., Piñeyro, M.D., Stehr, M., Robello, C., Flohé, L., Radi, R. J. Biol. Chem. (2004)
- Trypanothione reductase of Trypanosoma congolense: gene isolation, primary sequence determination, and comparison to glutathione reductase. Shames, S.L., Kimmel, B.E., Peoples, O.P., Agabian, N., Walsh, C.T. Biochemistry (1988)
- Sensitivity of parasites to free radical damage by antiparasitic drugs. Docampo, R. Chem. Biol. Interact. (1990)
- S-adenosylmethionine decarboxylase from Leishmania donovani. Molecular, genetic, and biochemical characterization of null mutants and overproducers. Roberts, S.C., Scott, J., Gasteier, J.E., Jiang, Y., Brooks, B., Jardim, A., Carter, N.S., Heby, O., Ullman, B. J. Biol. Chem. (2002)
- Glutathionylation of trypanosomal thiol redox proteins. Melchers, J., Dirdjaja, N., Ruppert, T., Krauth-Siegel, R.L. J. Biol. Chem. (2007)
- Sequence analysis of the tryparedoxin peroxidase gene from Crithidia fasciculata and its functional expression in Escherichia coli. Montemartini, M., Nogoceke, E., Singh, M., Steinert, P., Flohé, L., Kalisz, H.M. J. Biol. Chem. (1998)
- Catalytic properties, thiol pK value, and redox potential of Trypanosoma brucei tryparedoxin. Reckenfelderbäumer, N., Krauth-Siegel, R.L. J. Biol. Chem. (2002)
- Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi. Ariyanayagam, M.R., Oza, S.L., Mehlert, A., Fairlamb, A.H. J. Biol. Chem. (2003)
- Tryparedoxins from Crithidia fasciculata and Trypanosoma brucei: photoreduction of the redox disulfide using synchrotron radiation and evidence for a conformational switch implicated in function. Alphey, M.S., Gabrielsen, M., Micossi, E., Leonard, G.A., McSweeney, S.M., Ravelli, R.B., Tetaud, E., Fairlamb, A.H., Bond, C.S., Hunter, W.N. J. Biol. Chem. (2003)
- A second class of peroxidases linked to the trypanothione metabolism. Hillebrand, H., Schmidt, A., Krauth-Siegel, R.L. J. Biol. Chem. (2003)
- Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity. Stoll, V.S., Simpson, S.J., Krauth-Siegel, R.L., Walsh, C.T., Pai, E.F. Biochemistry (1997)
- Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase. Ponasik, J.A., Strickland, C., Faerman, C., Savvides, S., Karplus, P.A., Ganem, B. Biochem. J. (1995)
- Glyoxalase II of African trypanosomes is trypanothione-dependent. Irsch, T., Krauth-Siegel, R.L. J. Biol. Chem. (2004)
- Redox enzyme engineering: conversion of human glutathione reductase into a trypanothione reductase. Bradley, M., Bücheler, U.S., Walsh, C.T. Biochemistry (1991)
- Overexpression of Crithidia fasciculata trypanothione reductase and crystallization using a novel geometry. Strickland, C.L., Puchalski, R., Savvides, S.N., Karplus, P.A. Acta Crystallogr. D Biol. Crystallogr. (1995)
- Detection by HPLC of a trypanothione synthetase activity in vitro from Entamoeba histolytica. Ondarza, R.N., Hernandez, E., Iturbe, A., Hurtado, G., Tamayo, E.M. Biotechnol. Appl. Biochem. (1999)