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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Or22a  -  Odorant receptor 22a

Drosophila melanogaster

Synonyms: 22A.1, 22a, AN11, CG12193, DOR22A.1, ...
 
 
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High impact information on Or22a

  • We describe the expression of the Or22a and Or22b receptor genes, show localization to dendritic membranes, and find sexual dimorphism [1].
  • Analysis of a deletion mutant lacking Or22a, along with transgenic rescue experiments, confirms the mapping and demonstrates that an Or gene is required for olfactory function in vivo [1].
  • Or22a maps to the ab3A neuron, which responds to ethyl butyrate [1].
  • The induced proteins appear to be identical to three of the heat shock proteins (hsp 23, 22a, and 22b), as shown by electrophoretic mobilities and peptide mapping by partial proteolysis [2].
  • Aiming at a comprehensive characterization of MRRs in Drosophila melanogaster we measured odor-evoked calcium responses in olfactory sensory neurons that express the olfactory receptor Or22a [3].

References

  1. Integrating the molecular and cellular basis of odor coding in the Drosophila antenna. Dobritsa, A.A., van der Goes van Naters, W., Warr, C.G., Steinbrecht, R.A., Carlson, J.R. Neuron (2003) [Pubmed]
  2. Teratogens induce a subset of small heat shock proteins in Drosophila primary embryonic cell cultures. Buzin, C.H., Bournias-Vardiabasis, N. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  3. The molecular receptive range of an olfactory receptor in vivo (Drosophila melanogaster Or22a). Pelz, D., Roeske, T., Syed, Z., Bruyne, M., Galizia, C.G. J. Neurobiol. (2006) [Pubmed]
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