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Gene Review:

Uch - Ubiquitin carboxy-terminal hydrolase

Drosophila melanogaster

Synonyms: CG4265, Dmel\CG4265, P35122, UBL, UCH, ...

Tran, H., Dong, X. et al., Zhang, N. et al.

Hiep Tran,

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Disease relevance of Uch

Uch knockdown flies showed similar signs and pathological features of Parkinson's Disease in human. The knockdown flies exhibited progressive loss of Dopaminergic Neurons (DA neurons) in the brains following by shortage of dopamine and locomotor defects. DOI:

High impact information on Uch

Cloning and analysis of expression of a ubiquitin carboxyl terminal hydrolase expressed during oogenesis in Drosophila melanogaster [1].
Expression of ubiquitin-related enzymes in the suprachiasmatic nucleus with special reference to ubiquitin carboxy-terminal hydrolase UchL1 [2].
Dopaminergic Neurons (DA neurons) with reduced level of Uch showed high vulnerability to degeneration during the course of aging. The susceptibilities of DA neurons to Uch knockdown are varied among DA neuron clusters (loss of DA neurons were detected in DL1 cluster of larval brain and PPM2, PPM3, PPL2ab, VUM clusters of adult brain). DOI:

References

Cloning and analysis of expression of a ubiquitin carboxyl terminal hydrolase expressed during oogenesis in Drosophila melanogaster. Zhang, N., Wilkinson, K., Bownes, M. Dev. Biol. (1993) [Pubmed]
Expression of ubiquitin-related enzymes in the suprachiasmatic nucleus with special reference to ubiquitin carboxy-terminal hydrolase UchL1. Dong, X., Yagita, K., Zhang, J., Okamura, H. Biomed. Res. (2005) [Pubmed]

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AgaP_AGAP012113	Anopheles gambiae str. PEST
UCH3	Arabidopsis thaliana
AGOS_AGL314C	Ashbya gossypii ATCC 10895
UCHL3	Bos taurus
UCHL3	Canis lupus familiaris
uchl3	Danio rerio
UCHL3	Gallus gallus
UCHL3	Homo sapiens
KLLA0E09967g	Kluyveromyces lactis NRRL Y-1140
UCHL3	Macaca mulatta
MGG_01683	Magnaporthe oryzae 70-15
Uchl3	Mus musculus
NCU06372	Neurospora crassa OR74A
Os02g0654500	Oryza sativa Japonica Group
LOC452604	Pan troglodytes
Uchl3	Rattus norvegicus
YUH1	Saccharomyces cerevisiae S288c
uchl3	Xenopus (Silurana) tropicalis

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