Gene Review:
UCHL3 - ubiquitin carboxyl-terminal esterase L3...
Homo sapiens
Synonyms:
UCH-L3, Ubiquitin carboxyl-terminal hydrolase isozyme L3, Ubiquitin thioesterase L3
- Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1. Das, C., Hoang, Q.Q., Kreinbring, C.A., Luchansky, S.J., Meray, R.K., Ray, S.S., Lansbury, P.T., Ringe, D., Petsko, G.A. Proc. Natl. Acad. Sci. U.S.A. (2006)
- High expression of ubiquitin carboxy-terminal hydrolase-L1 and -L3 mRNA predicts early recurrence in patients with invasive breast cancer. Miyoshi, Y., Nakayama, S., Torikoshi, Y., Tanaka, S., Ishihara, H., Taguchi, T., Tamaki, Y., Noguchi, S. Cancer Sci. (2006)
- Molecular profiling of the immune response in colon cancer using protein microarrays: occurrence of autoantibodies to ubiquitin C-terminal hydrolase L3. Nam, M.J., Madoz-Gurpide, J., Wang, H., Lescure, P., Schmalbach, C.E., Zhao, R., Misek, D.E., Kuick, R., Brenner, D.E., Hanash, S.M. Proteomics (2003)
- The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase. Wilkinson, K.D., Lee, K.M., Deshpande, S., Duerksen-Hughes, P., Boss, J.M., Pohl, J. Science (1989)
- Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution. Johnston, S.C., Larsen, C.N., Cook, W.J., Wilkinson, K.D., Hill, C.P. EMBO J. (1997)
- Molecular cloning of chick UCH-6 which shares high similarity with human UCH-L3: its unusual substrate specificity and tissue distribution. Baek, S.H., Yoo, Y.J., Tanaka, K., Chung, C.H. Biochem. Biophys. Res. Commun. (1999)
- Nonhydrolyzable diubiquitin analogues are inhibitors of ubiquitin conjugation and deconjugation. Yin, L., Krantz, B., Russell, N.S., Deshpande, S., Wilkinson, K.D. Biochemistry (2000)
- Reduced ubiquitin C-terminal hydrolase-1 expression levels in dementia with Lewy bodies. Barrachina, M., Castaño, E., Dalfó, E., Maes, T., Buesa, C., Ferrer, I. Neurobiol. Dis. (2006)
- Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Liu, Y., Lashuel, H.A., Choi, S., Xing, X., Case, A., Ni, J., Yeh, L.A., Cuny, G.D., Stein, R.L., Lansbury, P.T. Chem. Biol. (2003)
- A novel in vitro assay for deubiquitination of I kappa B alpha. Strayhorn, W.D., Wadzinski, B.E. Arch. Biochem. Biophys. (2002)
- Activity profiling of deubiquitinating enzymes in cervical carcinoma biopsies and cell lines. Rolén, U., Kobzeva, V., Gasparjan, N., Ovaa, H., Winberg, G., Kisseljov, F., Masucci, M.G. Mol. Carcinog. (2006)
- Synthesis and characterization of fluorescent ubiquitin derivatives as highly sensitive substrates for the deubiquitinating enzymes UCH-L3 and USP-2. Tirat, A., Schilb, A., Riou, V., Leder, L., Gerhartz, B., Zimmermann, J., Worpenberg, S., Eidhoff, U., Freuler, F., Stettler, T., Mayr, L., Ottl, J., Leuenberger, B., Filipuzzi, I. Anal. Biochem. (2005)
- Substrate profiling of deubiquitin hydrolases with a positional scanning library and mass spectrometry. Mason, D.E., Ek, J., Peters, E.C., Harris, J.L. Biochemistry (2004)
- The binding site for UCH-L3 on ubiquitin: mutagenesis and NMR studies on the complex between ubiquitin and UCH-L3. Wilkinson, K.D., Laleli-Sahin, E., Urbauer, J., Larsen, C.N., Shih, G.H., Haas, A.L., Walsh, S.T., Wand, A.J. J. Mol. Biol. (1999)
- Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: synthesis of active site-directed probes. Ovaa, H., Galardy, P.J., Ploegh, H.L. Meth. Enzymol. (2005)