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Gene Review:

betP - glycine betaine transporter

Corynebacterium glutamicum ATCC 13032

Rübenhagen, R. et al., Peter, H. et al., Brocker, M. et al.

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Disease relevance of betP

This finding correlates with results demonstrating an identical shift when betP was expressed in E. coli instead of C. glutamicum [1].
Isolation, characterization, and expression of the Corynebacterium glutamicum betP gene, encoding the transport system for the compatible solute glycine betaine [2].

High impact information on betP

The secondary glycine betaine uptake system BetP of Corynebacterium glutamicum was purified from Escherichia coli membranes in strep-tagged form after heterologous expression of the betP gene and was reconstituted in E. coli lipids [1].
The betP gene, encoding the glycine betaine uptake carrier, was isolated by heterologous complementation of mutant strain Escherichia coli MKH13 [2].
The results indicate that mepA and nlpC, both encoding putative cell wall peptidases, are directly repressed by MtrA, whereas proP and betP, both encoding carriers for compatible solutes, are directly activated by MtrA [3].

References

Osmosensor and osmoregulator properties of the betaine carrier BetP from Corynebacterium glutamicum in proteoliposomes. Rübenhagen, R., Rönsch, H., Jung, H., Krämer, R., Morbach, S. J. Biol. Chem. (2000) [Pubmed]
Isolation, characterization, and expression of the Corynebacterium glutamicum betP gene, encoding the transport system for the compatible solute glycine betaine. Peter, H., Burkovski, A., Krämer, R. J. Bacteriol. (1996) [Pubmed]
Evidence for activator and repressor functions of the response regulator MtrA from Corynebacterium glutamicum. Brocker, M., Bott, M. FEMS Microbiol. Lett. (2006) [Pubmed]

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