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Gene Review:

FOXN2 - forkhead box N2

Homo sapiens

Synonyms: Forkhead box protein N2, HTLF, Human T-cell leukemia virus enhancer factor

Li, C. et al., Ariyama, Y. et al.

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Disease relevance of FOXN2

HTLF is a unique cellular gene that may function in the transcriptional regulation of HTLV-I LTR [1].

High impact information on FOXN2

Chromosome mapping of the HTLF gene demonstrated that it was localized to human chromosome 2p16-p22 [1].
Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein HTLF [1].
Chromosomes 14q32 and 2p16-22 harbor TCL1 and a transcription factor, HTLF (human T-cell leukemia virus enhancer factor), respectively [2].
Moreover, expression of HTLF was not elevated in the ATL cell lines bearing multiplication of 2p [2].

References

Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein HTLF. Li, C., Lusis, A.J., Sparkes, R., Tran, S.M., Gaynor, R. Genomics (1992) [Pubmed]
Chromosomal imbalances in adult T-cell leukemia revealed by comparative genomic hybridization: gains at 14q32 and 2p16-22 in cell lines. Ariyama, Y., Mori, T., Shinomiya, T., Sakabe, T., Fukuda, Y., Kanamaru, A., Yamada, Y., Isobe, M., Seto, M., Nakamura, Y., Inazawa, J. J. Hum. Genet. (1999) [Pubmed]

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