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Gene Review:

ndh - NADH dehydrogenase

Corynebacterium glutamicum ATCC 13032

Nantapong, N. et al., Matsushita, K. et al., Nantapong, N. et al.

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Disease relevance of ndh

Effect of NADH dehydrogenase-disruption and over-expression on respiration-related metabolism in Corynebacterium glutamicum KY9714 [1].

High impact information on ndh

However, in the strain that lacked NDH-2, membrane L-lactate oxidase activity increased, while NDH-2 over-expression led to decreased L-lactate and malate oxidase activities [1].
In this study, we tried to purify NADPH oxidase and NADH dehydrogenase activities from the membranes of C. glutamicum [2].
UV-visible and fluorescence analyses of the purified enzyme showed that NDH-2 of C. glutamicum contained non-covalently bound FAD but not covalently bound FMN [3].
Electron transfer ability from NADH to menaquinone and from NADPH to oxygen of type II NADH dehydrogenase of Corynebacterium glutamicum [3].

Chemical compound and disease context of ndh

NADH dehydrogenase of Corynebacterium glutamicum. Purification of an NADH dehydrogenase II homolog able to oxidize NADPH [2].

Associations of ndh with chemical compounds

Thus, NADH dehydrogenase of C. glutamicum was shown to be rather unique in having a relatively high reactivity toward NADPH [2].
These results suggest that coupling of LDH and the membrane L-lactate oxidase system, together with the malate-dependent NADH oxidase system, operates to oxidize NADH when the NDH-2 function is defective in C. glutamicum [1].

References

Effect of NADH dehydrogenase-disruption and over-expression on respiration-related metabolism in Corynebacterium glutamicum KY9714. Nantapong, N., Kugimiya, Y., Toyama, H., Adachi, O., Matsushita, K. Appl. Microbiol. Biotechnol. (2004) [Pubmed]
NADH dehydrogenase of Corynebacterium glutamicum. Purification of an NADH dehydrogenase II homolog able to oxidize NADPH. Matsushita, K., Otofuji, A., Iwahashi, M., Toyama, H., Adachi, O. FEMS Microbiol. Lett. (2001) [Pubmed]
Electron transfer ability from NADH to menaquinone and from NADPH to oxygen of type II NADH dehydrogenase of Corynebacterium glutamicum. Nantapong, N., Otofuji, A., Migita, C.T., Adachi, O., Toyama, H., Matsushita, K. Biosci. Biotechnol. Biochem. (2005) [Pubmed]

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