Disease relevance of CG3488

• Further, overexpression of a CG3488 transgene rescues this obesity phenotype [1].

High impact information on CG3488

• Overall, the data suggests that CG3488 functions as a lipase and that analyses of its homologs will provide unique insights into lipid metabolism in many species [1].
• A genetic analysis shows that heterozygosity for a chromosomal deletion that removes CG3488 dominantly enhances the excess lipid phenotype associated with a mutation in adipose, an uncloned obesity gene [1].
• We report a multidisciplinary analysis of CG3488, a predicted gene adjacent to Mothers against dpp in Drosophila melanogaster [1].
• A computational analysis shows that CG3488 contains a number of conserved domains present in enzymes capable of lipid hydrolysis [1].
• A phylogenetic analysis shows that CG3488 is the homolog of human alpha/beta hydrolase2 and that these genes belong to a novel multigene family with members in animals, plants, fungi, and bacteria [1].

References