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Gene Review

slp2  -  sloppy paired 2

Drosophila melanogaster

Synonyms: CG2939, Dmel\CG2939, Dmslp2, FD7, Fork head domain transcription factor slp2, ...
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High impact information on slp2

  • We propose that by virtue of their ability to activate wg and repress en expression, the distribution of the slp proteins define the wg-competent and en-competent groups [1].
  • Removal of slp gene function causes embryos to exhibit a severe pair-rule/segment polarity phenotype [1].
  • The phenotypes of embryos containing various combinations of functional slp genes suggest that for early slp function, until gastrulation, only slp1 is required [2].
  • Low levels of terminal system activity seem to potentiate bcd as an activator of slp, whereas high levels down-regulate bcd rendering it inactive [3].
  • In Tribolium, homologs of almost all the eight canonical Drosophila pair-rule genes are expressed in pair-rule domains, but only five have pair-rule functions. even-skipped, runt and odd-skipped act as primary pair-rule genes, while the functions of paired (prd) and sloppy-paired (slp) are secondary [4].

Biological context of slp2

  • In contrast, misexpression of either slp1 or slp2 causes downregulation of glial cell-specific genes and alters the fate of glial and neuronal cells [5].

Anatomical context of slp2

  • The sloppy-paired (slp) locus contains two genes (slp1 and slp2) that are expressed in overlapping striped patterns in the presumptive thorax and abdomen [6].

Regulatory relationships of slp2

  • Similarly, slp is required to activate wg in alternate parasegments and to maintain the remaining wg stripes in both insects [4].

Other interactions of slp2

  • In this paper, we also show that gsb interacts with slp and prevents Slp from specifying NB4-2 identity [7].
  • We also propose that in wg-expressing ectodermal cells, slp is an integral component in an autocrine feedback loop of Wg signaling [8].


  1. Localized expression of sloppy paired protein maintains the polarity of Drosophila parasegments. Cadigan, K.M., Grossniklaus, U., Gehring, W.J. Genes Dev. (1994) [Pubmed]
  2. Functional redundancy: the respective roles of the two sloppy paired genes in Drosophila segmentation. Cadigan, K.M., Grossniklaus, U., Gehring, W.J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  3. Three maternal coordinate systems cooperate in the patterning of the Drosophila head. Grossniklaus, U., Cadigan, K.M., Gehring, W.J. Development (1994) [Pubmed]
  4. Evolutionary flexibility of pair-rule patterning revealed by functional analysis of secondary pair-rule genes, paired and sloppy-paired in the short-germ insect, Tribolium castaneum. Choe, C.P., Brown, S.J. Dev. Biol. (2007) [Pubmed]
  5. Sloppy paired 1/2 regulate glial cell fates by inhibiting Gcm Function. Mondal, S., Ivanchuk, S.M., Rutka, J.T., Boulianne, G.L. Glia (2007) [Pubmed]
  6. Groucho-dependent repression by sloppy-paired 1 differentially positions anterior pair-rule stripes in the Drosophila embryo. Andrioli, L.P., Oberstein, A.L., Corado, M.S., Yu, D., Small, S. Dev. Biol. (2004) [Pubmed]
  7. Sloppy paired acts as the downstream target of wingless in the Drosophila CNS and interaction between sloppy paired and gooseberry inhibits sloppy paired during neurogenesis. Bhat, K.M., van Beers, E.H., Bhat, P. Development (2000) [Pubmed]
  8. Wingless effects mesoderm patterning and ectoderm segmentation events via induction of its downstream target sloppy paired. Lee, H.H., Frasch, M. Development (2000) [Pubmed]
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