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High impact information on grna
- CONCLUSION: In support of the duplication-degeneration-complementation model of duplicate gene retention, partitioning of expression between grna and grnb was observed in the intermediate cell mass and yolk syncytial layer, respectively [1].
- Chromosomal localization of the four progranulin (grn) genes reveals syntenic conservation for grna only, suggesting that it is the true orthologue of mammalian grn [1].
Analytical, diagnostic and therapeutic context of grna
- RT-PCR and whole-mount in situ hybridization analysis of zebrafish grns during development reveals that combined expression of grna and grnb, but not grn1 and grn2, recapitulate many of the expression patterns observed for the murine counterpart [1].
References
- The zebrafish progranulin gene family and antisense transcripts. Cadieux, B., Chitramuthu, B.P., Baranowski, D., Bennett, H.P. BMC Genomics (2005) [Pubmed]
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