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MeSH Review

Genes, Duplicate

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Disease relevance of Genes, Duplicate


High impact information on Genes, Duplicate


Chemical compound and disease context of Genes, Duplicate


Biological context of Genes, Duplicate


Associations of Genes, Duplicate with chemical compounds

  • Silencing of duplicate genes: a null allele polymorphism for lactate dehydrogenase in brown trout (Salmo trutta) [10].
  • Intron sequences from each duplicate gene yielded phylogenetic trees that were not significantly different from each other in topology [11].
  • We explore the dynamics of the recruitment of new duplicate genes for chalcone synthase, the enzyme that catalyzes the first committed step of flavonoid biosynthesis, and for the myb family of transcriptional activators [12].
  • Estrogen receptors in Xenopus: duplicate genes, splice variants, and tissue-specific expression [13].
  • The regulatory effects of allelic substitution at the trans-acting mapP locus and of dietary glucose on the expression of the duplicate genes for alpha-amylase (Amy) in Drosophila melanogaster were examined in the anterior midgut and posterior midgut regions of mature flies [14].

Gene context of Genes, Duplicate

  • Comparison of the D. melanogaster and D. simulans hsp70 genes reveals whole-family fixed differences, consistent with rapid propagation of novel mutations among duplicate genes [15].
  • CONCLUSION: In support of the duplication-degeneration-complementation model of duplicate gene retention, partitioning of expression between grna and grnb was observed in the intermediate cell mass and yolk syncytial layer, respectively [16].
  • Mouse alcohol dehydrogenase isozymes: products of closely localized duplicate genes exhibiting divergent kinetic properties [17].
  • Sequence based analyses indicate that PTM3 (Populus tremuloides MADS-box 3), and a duplicate gene PTM4, are related to the SEPALLATA1-and 2-class of MADS-box genes [18].
  • Thus, the zebrafish duplicate genes appear to have reciprocally lost expression domains present in the sox11 gene of the last common ancestor of tetrapods and zebrafish [19].

Analytical, diagnostic and therapeutic context of Genes, Duplicate


  1. Molecular characterization of multidrug-resistant Salmonella enterica subsp. enterica serovar Typhimurium isolates from swine. Gebreyes, W.A., Altier, C. J. Clin. Microbiol. (2002) [Pubmed]
  2. Tenascin-X deficiency is associated with Ehlers-Danlos syndrome. Burch, G.H., Gong, Y., Liu, W., Dettman, R.W., Curry, C.J., Smith, L., Miller, W.L., Bristow, J. Nat. Genet. (1997) [Pubmed]
  3. Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. Tsuchida, S., Matsusaka, T., Chen, X., Okubo, S., Niimura, F., Nishimura, H., Fogo, A., Utsunomiya, H., Inagami, T., Ichikawa, I. J. Clin. Invest. (1998) [Pubmed]
  4. The maize auxotrophic mutant orange pericarp is defective in duplicate genes for tryptophan synthase beta. Wright, A.D., Moehlenkamp, C.A., Perrot, G.H., Neuffer, M.G., Cone, K.C. Plant Cell (1992) [Pubmed]
  5. The maize duplicate genes narrow sheath1 and narrow sheath2 encode a conserved homeobox gene function in a lateral domain of shoot apical meristems. Nardmann, J., Ji, J., Werr, W., Scanlon, M.J. Development (2004) [Pubmed]
  6. Consequences of Hox gene duplication in the vertebrates: an investigation of the zebrafish Hox paralogue group 1 genes. McClintock, J.M., Carlson, R., Mann, D.M., Prince, V.E. Development (2001) [Pubmed]
  7. The cps gene cluster of Salmonella strain LT2 includes a second mannose pathway: sequence of two genes and relationship to genes in the rfb gene cluster. Stevenson, G., Lee, S.J., Romana, L.K., Reeves, P.R. Mol. Gen. Genet. (1991) [Pubmed]
  8. Physical and gene mapping of chloroplast DNA from Atriplex triangularis and Cucumis sativa. Palmer, J.D. Nucleic Acids Res. (1982) [Pubmed]
  9. Biology of a duplicate gene system with glucose 6-phosphate dehydrogenase activity in Drosophila melanogaster: genetic analysis and differences in fitness components and reaction to environmental parameters among Zw genotypes. Giesel, J.T. Biochem. Genet. (1976) [Pubmed]
  10. Silencing of duplicate genes: a null allele polymorphism for lactate dehydrogenase in brown trout (Salmo trutta). Allendorf, F.W., Ståhl, G., Ryman, N. Mol. Biol. Evol. (1984) [Pubmed]
  11. Phylogeny of salmonine fishes based on growth hormone introns: Atlantic (Salmo) and Pacific (Oncorhynchus) salmon are not sister taxa. Oakley, T.H., Phillips, R.B. Mol. Phylogenet. Evol. (1999) [Pubmed]
  12. Comparative genomics of chalcone synthase and Myb genes in the grass family. Oberholzer, V., Durbin, M.L., Clegg, M.T. Genes Genet. Syst. (2000) [Pubmed]
  13. Estrogen receptors in Xenopus: duplicate genes, splice variants, and tissue-specific expression. Wu, K.H., Tobias, M.L., Thornton, J.W., Kelley, D.B. Gen. Comp. Endocrinol. (2003) [Pubmed]
  14. Tissue-specific and dietary control of alpha-amylase gene expression in the adult midgut of Drosophila melanogaster. Thompson, D.B., Treat-Clemons, L.G., Doane, W.W. J. Exp. Zool. (1992) [Pubmed]
  15. Rapid concerted evolution via gene conversion at the Drosophila hsp70 genes. Bettencourt, B.R., Feder, M.E. J. Mol. Evol. (2002) [Pubmed]
  16. The zebrafish progranulin gene family and antisense transcripts. Cadieux, B., Chitramuthu, B.P., Baranowski, D., Bennett, H.P. BMC Genomics (2005) [Pubmed]
  17. Mouse alcohol dehydrogenase isozymes: products of closely localized duplicate genes exhibiting divergent kinetic properties. Holmes, R.S., Albanese, R., Whitehead, F.D., Duley, J.A. J. Exp. Zool. (1981) [Pubmed]
  18. SEP-class genes in Populus tremuloides and their likely role in reproductive survival of poplar trees. Cseke, L.J., Cseke, S.B., Ravinder, N., Taylor, L.C., Shankar, A., Sen, B., Thakur, R., Karnosky, D.F., Podila, G.K. Gene (2005) [Pubmed]
  19. Expression of sox11 gene duplicates in zebrafish suggests the reciprocal loss of ancestral gene expression patterns in development. de Martino, S., Yan, Y.L., Jowett, T., Postlethwait, J.H., Varga, Z.M., Ashworth, A., Austin, C.A. Dev. Dyn. (2000) [Pubmed]
  20. Molecular cloning and characterization of a greenbug (Schizaphis graminum) cDNA encoding acetylcholinesterase possibly evolved from a duplicate gene lineage. Gao, J.R., Kambhampati, S., Zhu, K.Y. Insect Biochem. Mol. Biol. (2002) [Pubmed]
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