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Gene Review

GluRIIB  -  Glutamate receptor IIB

Drosophila melanogaster

Synonyms: CG7234, DGluIIB, DGluR-IIB, DGluRIIB, DmelGluRIIB, ...
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High impact information on GluRIIB

  • Mutations that eliminate DGluRIIA (but not DGluRIIB) or transgenic constructs that increase DGluRIIA expression were generated [1].
  • Glutamate receptor expression regulates quantal size and quantal content at the Drosophila neuromuscular junction [2].
  • Consistent with previous studies showing that extracellular glutamate regulates postsynaptic glutamate receptor clustering, gb mutants show a large (200-300%) increase in the number of postsynaptic glutamate receptors [3].
  • We hypothesize that glutamate receptors and DLG cluster in response to parallel signals from the presynaptic neuron, after which DLG regulates subunit composition by stabilizing (probably indirectly) receptors that contain the GluRIIB subunit [4].
  • DGluRIIA and DGluRIIB compete with each other for access to DGluRIII and subsequent localization to the synapse [5].

Biological context of GluRIIB


Anatomical context of GluRIIB

  • Glutamatergic Drosophila neuromuscular junctions contain two spatially, biophysically, and pharmacologically distinct subtypes of postsynaptic glutamate receptor (GluR) [7].

Associations of GluRIIB with chemical compounds

  • Electrophysiological analysis shows an overall loss of functional postsynaptic glutamate receptors, along with changes in receptor biophysical properties that are consistent with a selective loss of GluRIIB from the synapse [4].

Other interactions of GluRIIB


  1. Genetic analysis of glutamate receptors in Drosophila reveals a retrograde signal regulating presynaptic transmitter release. Petersen, S.A., Fetter, R.D., Noordermeer, J.N., Goodman, C.S., DiAntonio, A. Neuron (1997) [Pubmed]
  2. Glutamate receptor expression regulates quantal size and quantal content at the Drosophila neuromuscular junction. DiAntonio, A., Petersen, S.A., Heckmann, M., Goodman, C.S. J. Neurosci. (1999) [Pubmed]
  3. Nonvesicular release of glutamate by glial xCT transporters suppresses glutamate receptor clustering in vivo. Augustin, H., Grosjean, Y., Chen, K., Sheng, Q., Featherstone, D.E. J. Neurosci. (2007) [Pubmed]
  4. Discs-large (DLG) is clustered by presynaptic innervation and regulates postsynaptic glutamate receptor subunit composition in Drosophila. Chen, K., Featherstone, D.E. BMC Biol. (2005) [Pubmed]
  5. Differential localization of glutamate receptor subunits at the Drosophila neuromuscular junction. Marrus, S.B., Portman, S.L., Allen, M.J., Moffat, K.G., DiAntonio, A. J. Neurosci. (2004) [Pubmed]
  6. The postsynaptic glutamate receptor subunit DGluR-IIA mediates long-term plasticity in Drosophila. Sigrist, S.J., Thiel, P.R., Reiff, D.F., Schuster, C.M. J. Neurosci. (2002) [Pubmed]
  7. The 4.1 protein coracle mediates subunit-selective anchoring of Drosophila glutamate receptors to the postsynaptic actin cytoskeleton. Chen, K., Merino, C., Sigrist, S.J., Featherstone, D.E. J. Neurosci. (2005) [Pubmed]
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