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Gene Review

cora  -  coracle

Drosophila melanogaster

Synonyms: CG11949, COR, Cor, Cora, Coracle, ...
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High impact information on cora


Biological context of cora


Anatomical context of cora


Associations of cora with chemical compounds

  • We identified coracle, a homolog of mammalian brain 4.1 proteins, in yeast two-hybrid and genetic screens for proteins that interact with and localize Drosophila glutamate receptors [6].

Other interactions of cora

  • Transient apical polarization of Gliotactin and Coracle is required for parallel alignment of wing hairs in Drosophila [5].
  • Taken together, our results indicate that Gli and Cora function as the first-identified members of a long-predicted, frizzled-independent parallel alignment mechanism [5].
  • Consistent with this notion, immunoprecipitation and in vitro binding studies demonstrate that the amino-terminal 383 amino acids of Coracle and cytoplasmic domain of Neurexin interact directly [2].
  • Studies of coracle, a Drosophila Protein 4.1 homologue, provide an opportunity to examine the genetic functions of this gene family. coracle was originally identified as a dominant suppressor of EgfrElp, a hypermorphic form of the Drosophila Epidermal growth factor receptor gene [7].


  1. Gliotactin, a novel marker of tricellular junctions, is necessary for septate junction development in Drosophila. Schulte, J., Tepass, U., Auld, V.J. J. Cell Biol. (2003) [Pubmed]
  2. A conserved functional domain of Drosophila coracle is required for localization at the septate junction and has membrane-organizing activity. Ward, R.E., Lamb, R.S., Fehon, R.G. J. Cell Biol. (1998) [Pubmed]
  3. A Drosophila homologue of membrane-skeleton protein 4.1 is associated with septate junctions and is encoded by the coracle gene. Fehon, R.G., Dawson, I.A., Artavanis-Tsakonas, S. Development (1994) [Pubmed]
  4. The protein 4.1, ezrin, radixin, moesin (FERM) domain of Drosophila Coracle, a cytoplasmic component of the septate junction, provides functions essential for embryonic development and imaginal cell proliferation. Ward, R.E., Schweizer, L., Lamb, R.S., Fehon, R.G. Genetics (2001) [Pubmed]
  5. Transient apical polarization of Gliotactin and Coracle is required for parallel alignment of wing hairs in Drosophila. Venema, D.R., Zeev-Ben-Mordehai, T., Auld, V.J. Dev. Biol. (2004) [Pubmed]
  6. The 4.1 protein coracle mediates subunit-selective anchoring of Drosophila glutamate receptors to the postsynaptic actin cytoskeleton. Chen, K., Merino, C., Sigrist, S.J., Featherstone, D.E. J. Neurosci. (2005) [Pubmed]
  7. Drosophila coracle, a member of the protein 4.1 superfamily, has essential structural functions in the septate junctions and developmental functions in embryonic and adult epithelial cells. Lamb, R.S., Ward, R.E., Schweizer, L., Fehon, R.G. Mol. Biol. Cell (1998) [Pubmed]
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