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Gene Review

GluRIIA  -  Glutamate receptor IIA

Drosophila melanogaster

Synonyms: CG6992, D-GluRIIA, DGluR-II, DGluR-IIA, DGluR2a, ...
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High impact information on GluRIIA


Biological context of GluRIIA

  • DGluRIII is required for the synaptic localization of DGluRIIA and DGluRIIB and for synaptic transmission [5].
  • This study opens the way for a further characterization of in vivo glutamate receptor assembly and trafficking using the efficient genetics of Drosophila [6].
  • We cloned the gene encoding a second muscle-specific glutamate receptor, DGluRIIB, which is closely related to the previously identified DGluRIIA and located adjacent to it in the genome [7].
  • Thus, editing at these sites would appear to involve a mechanism whereby the edited exon forms a base-paired secondary structure with the distant conserved noncoding sequences located in adjacent downstream introns, similar to the mechanism shown for A-to-I RNA editing of mammalian glutamate receptor subunits (GluRs) [8].
  • We show that DGluR-II mRNA is first expressed at stage 12 of embryogenesis and that expression is detected in developing dorsal, lateral, and ventral somatic muscles within the next 2 hr [9].

Anatomical context of GluRIIA


Associations of GluRIIA with chemical compounds

  • RESULTS: There are thought to be two classes of glutamate receptors in the Drosophila NMJ: 1) receptors that contain the subunit GluRIIA, and 2) receptors that contain the subunit GluRIIB [11].
  • Isoflurane did not affect postsynaptic glutamate receptor function detectably, in that the amplitudes, areas and decay times of spontaneous miniature EJCs were unchanged at any concentration [12].
  • The specificity of the response was tested with a glutamate receptor antagonist (argiotoxin 636) [13].
  • Sterol-enriched lipid rafts have been involved in Drosophila membrane signalling such as Hedgehog targeting and glutamate receptor ligand-affinity regulation [14].
  • Interestingly, we identified two non-heat-shock protein genes that were specifically responsive to ethanol. glr-2 was the only glutamate receptor gene to be induced by ethanol [15].

Physical interactions of GluRIIA


Regulatory relationships of GluRIIA


Other interactions of GluRIIA


Analytical, diagnostic and therapeutic context of GluRIIA


  1. Postsynaptic translation affects the efficacy and morphology of neuromuscular junctions. Sigrist, S.J., Thiel, P.R., Reiff, D.F., Lachance, P.E., Lasko, P., Schuster, C.M. Nature (2000) [Pubmed]
  2. Molecular cloning of an invertebrate glutamate receptor subunit expressed in Drosophila muscle. Schuster, C.M., Ultsch, A., Schloss, P., Cox, J.A., Schmitt, B., Betz, H. Science (1991) [Pubmed]
  3. Developmental regulation of glutamate receptor field size by nonvesicular glutamate release. Featherstone, D.E., Rushton, E., Broadie, K. Nat. Neurosci. (2002) [Pubmed]
  4. The translational repressor Pumilio regulates presynaptic morphology and controls postsynaptic accumulation of translation factor eIF-4E. Menon, K.P., Sanyal, S., Habara, Y., Sanchez, R., Wharton, R.P., Ramaswami, M., Zinn, K. Neuron (2004) [Pubmed]
  5. Differential localization of glutamate receptor subunits at the Drosophila neuromuscular junction. Marrus, S.B., Portman, S.L., Allen, M.J., Moffat, K.G., DiAntonio, A. J. Neurosci. (2004) [Pubmed]
  6. Four different subunits are essential for expressing the synaptic glutamate receptor at neuromuscular junctions of Drosophila. Qin, G., Schwarz, T., Kittel, R.J., Schmid, A., Rasse, T.M., Kappei, D., Ponimaskin, E., Heckmann, M., Sigrist, S.J. J. Neurosci. (2005) [Pubmed]
  7. Genetic analysis of glutamate receptors in Drosophila reveals a retrograde signal regulating presynaptic transmitter release. Petersen, S.A., Fetter, R.D., Noordermeer, J.N., Goodman, C.S., DiAntonio, A. Neuron (1997) [Pubmed]
  8. RNA editing of the Drosophila para Na(+) channel transcript. Evolutionary conservation and developmental regulation. Hanrahan, C.J., Palladino, M.J., Ganetzky, B., Reenan, R.A. Genetics (2000) [Pubmed]
  9. Drosophila glutamate receptor RNA expression in embryonic and larval muscle fibers. Currie, D.A., Truman, J.W., Burden, S.J. Dev. Dyn. (1995) [Pubmed]
  10. An essential Drosophila glutamate receptor subunit that functions in both central neuropil and neuromuscular junction. Featherstone, D.E., Rushton, E., Rohrbough, J., Liebl, F., Karr, J., Sheng, Q., Rodesch, C.K., Broadie, K. J. Neurosci. (2005) [Pubmed]
  11. Discs-large (DLG) is clustered by presynaptic innervation and regulates postsynaptic glutamate receptor subunit composition in Drosophila. Chen, K., Featherstone, D.E. BMC Biol. (2005) [Pubmed]
  12. Isoflurane depresses glutamate release by reducing neuronal excitability at the Drosophila neuromuscular junction. Sandstrom, D.J. J. Physiol. (Lond.) (2004) [Pubmed]
  13. Synaptic activity modifies the levels of Dorsal and Cactus at the neuromuscular junction of Drosophila. Bolatto, C., Chifflet, S., Megighian, A., Cantera, R. J. Neurobiol. (2003) [Pubmed]
  14. Cholesterol-depleting compounds modulate K+-currents in Drosophila Kenyon cells. Gasque, G., Labarca, P., Darszon, A. FEBS Lett. (2005) [Pubmed]
  15. Ethanol-response genes and their regulation analyzed by a microarray and comparative genomic approach in the nematode Caenorhabditis elegans. Kwon, J.Y., Hong, M., Choi, M.S., Kang, S., Duke, K., Kim, S., Lee, S., Lee, J. Genomics (2004) [Pubmed]
  16. The 4.1 protein coracle mediates subunit-selective anchoring of Drosophila glutamate receptors to the postsynaptic actin cytoskeleton. Chen, K., Merino, C., Sigrist, S.J., Featherstone, D.E. J. Neurosci. (2005) [Pubmed]
  17. Coordinating structural and functional synapse development: postsynaptic p21-activated kinase independently specifies glutamate receptor abundance and postsynaptic morphology. Albin, S.D., Davis, G.W. J. Neurosci. (2004) [Pubmed]
  18. Retrograde control of synaptic transmission by postsynaptic CaMKII at the Drosophila neuromuscular junction. Haghighi, A.P., McCabe, B.D., Fetter, R.D., Palmer, J.E., Hom, S., Goodman, C.S. Neuron (2003) [Pubmed]
  19. Kinetic properties of glutamate receptor channels in cultured embryonic Drosophila myotubes. Chang, H., Kidokoro, Y. Jpn. J. Physiol. (1996) [Pubmed]
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