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Gene Review

ICR1  -  ichthyosis congenita I, erythromatous...

Homo sapiens

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Disease relevance of ICR1

  • The presence of ICR1 and ICR2-like sequences in BMV genomic 5' (+)RNAs and the tobamovirus 5' (-)RNAs may reflect promoter arrangements of primordial genomic RNAs ancestral to both modern plant viruses and eukaryotic tRNAs [1].

High impact information on ICR1


  1. Similarities among plant virus (+) and (-) RNA termini imply a common ancestry with promoters of eukaryotic tRNAs. Marsh, L.E., Pogue, G.P., Hall, T.C. Virology (1989) [Pubmed]
  2. Epigenetic mutations in 11p15 in Silver-Russell syndrome are restricted to the telomeric imprinting domain. Eggermann, T., Schönherr, N., Meyer, E., Obermann, C., Mavany, M., Eggermann, K., Ranke, M.B., Wollmann, H.A. J. Med. Genet. (2006) [Pubmed]
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