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Gene Review:

slam - slow as molasses

Drosophila melanogaster

Synonyms: CG9506, Dmel\CG9506, Slam, wdo

Stein, J.A. et al., Lecuit, T. et al., Berezikov, E. et al.

Lecuit, Samanta, Wieschaus,

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High impact information on slam

Consistent with this phenotype, we found that slam is one of the earliest genes to be transcribed in the embryo, and Slam protein localizes to the growing basal-lateral membrane during blastoderm formation, but Slam is not detected during later stages of embryogenesis [1].
Our results suggest that developmental induction of Slam organizes the polarized growth of membrane via the recruitment of membrane-targeting proteins at adherens junctions [2].
RESULTS: In addition to previously characterized BS, Doc, F, G, I and Jockey elements, we have identified new non-LTR retrotransposons: Waldo, You and JuanDm [3].

Anatomical context of slam

Because slam RNA and protein are expressed earlier than the time when we observe defects in germ cell migration, we propose that Slam is required for the localization of a signal to the basal side of blastoderm cells that is needed later in the posterior midgut to guide germ cells [1].

References

Slow as molasses is required for polarized membrane growth and germ cell migration in Drosophila. Stein, J.A., Broihier, H.T., Moore, L.A., Lehmann, R. Development (2002) [Pubmed]
slam encodes a developmental regulator of polarized membrane growth during cleavage of the Drosophila embryo. Lecuit, T., Samanta, R., Wieschaus, E. Dev. Cell (2002) [Pubmed]
A search for reverse transcriptase-coding sequences reveals new non-LTR retrotransposons in the genome of Drosophila melanogaster. Berezikov, E., Bucheton, A., Busseau, I. Genome Biol. (2000) [Pubmed]

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