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Gene Review

hxuA  -  heme:hemopexin utilization protein A

Haemophilus influenzae 86-028NP

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Disease relevance of hxuA

  • Nucleotide sequence analysis of the hxuA gene from Hib strain DL42, together with N-terminal amino acid analysis of HxuA protein purified from Hib culture supernatant, revealed that this protein was synthesized as a 101 kDa precursor with a leader peptide that was removed to yield a 99 kDa protein [1].
  • The utilization of heme bound to the serum glycoprotein hemopexin by Haemophilus influenzae type b (Hib) strain DL42 requires the presence of the 100-kDa heme:hemopexin-binding protein encoded by the hxuA gene (M. S. Hanson, S. E. Pelzel, J. Latimer, U. Muller-Eberhard, and E. J. Hansen, Proc. Natl. Acad. Sci. USA 89:1973-1977, 1992) [2].

High impact information on hxuA

  • A Hib hxuA mutant was used to screen an NTHI genomic DNA library and an NTHI gene was cloned that complemented the mutation in this Hib strain [1].
  • A set of three isogenic Hib mutants with cat cartridges inserted individually into their hxuA, hxuB, and hxuC genes was constructed [2].

Analytical, diagnostic and therapeutic context of hxuA

  • Southern blot analysis of chromosomal DNA from four Hib and four non-typeable H. influenzae (NTHI) strains detected the presence of a single band in each strain that hybridized a Hib hxuA gene probe [1].


  1. The 100 kDa haem:haemopexin-binding protein of Haemophilus influenzae: structure and localization. Cope, L.D., Thomas, S.E., Latimer, J.L., Slaughter, C.A., Müller-Eberhard, U., Hansen, E.J. Mol. Microbiol. (1994) [Pubmed]
  2. A gene cluster involved in the utilization of both free heme and heme:hemopexin by Haemophilus influenzae type b. Cope, L.D., Yogev, R., Muller-Eberhard, U., Hansen, E.J. J. Bacteriol. (1995) [Pubmed]
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