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Gene Review:

ddc - DABA decarboxylase; DABA-DC

Haemophilus influenzae 86-028NP

Yamamoto, S. et al., Ikai, H. et al.

Yamamoto, Mutoh, Tsuzuki, Ikai, Nakao, Shinoda, Narimatsu, Miyoshi,

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Disease relevance of ddc

In the present study, the ddc gene encoding DABA DC from Enterobacter aerogenes ATCC 13048 was cloned and characterized [1].
The deduced amino acid sequence was highly similar to those of Acinetobacter baumannii and Haemophilus influenzae DABA DCs encoded by the ddc genes [1].
Furthermore, PCR analysis revealed the distribution of E. aerogenes ddc homologs in some other species of Enterobacteriaceae [1].

High impact information on ddc

L-2,4-diaminobutyrate decarboxylase (DABA DC) catalyzes the formation of 1,3-diaminopropane (DAP) from DABA [1].
We previously cloned and sequenced the Acinetobacter baumannii dat and ddc genes encoding L-2,4-diaminobutyrate: 2-ketoglutarate 4-aminotransferase (DABA AT) and DABA decarboxylase, respectively, involved in the 1,3-diaminopropane (DAP) production pathway [2].

References

Cloning and characterization of the ddc homolog encoding L-2,4-diaminobutyrate decarboxylase in Enterobacter aerogenes. Yamamoto, S., Mutoh, N., Tsuzuki, D., Ikai, H., Nakao, H., Shinoda, S., Narimatsu, S., Miyoshi, S.I. Biol. Pharm. Bull. (2000) [Pubmed]
Two genes involved in the 1,3-diaminopropane production pathway in Haemophilus influenzae. Ikai, H., Yamamoto, S. Biol. Pharm. Bull. (1998) [Pubmed]

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