The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

trk  -  trunk

Drosophila melanogaster

Synonyms: CG5619, Dmel\CG5619, Protein trunk, fs(2)trunk
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on trk

  • Here we report that trunk (trk), a gene required for activity of the tor receptor, encodes a protein that resembles spz in several respects [1].
  • Furthermore, the carboxy-terminal domain of trk has a similar arrangement of cysteines to that of spz [1].
  • A novel modular mosaic of cell adhesion motifs in the extracellular domains of the neurogenic trk and trkB tyrosine kinase receptors [2].
  • The trk family of receptor tyrosine kinases is crucial for neuronal survival in the vertebrate nervous system, however both C. elegans and Drosophila lack genes encoding trks or their ligands [3].
  • However, it is not well understood how this signal is generated, although it is known to depend on the activity of many genes such as torso-like (tsl) and trunk (trk) [4].

Biological context of trk

  • Using the trk, abl and src families of tyrosine kinase encoded proto-oncogenes, we discuss here new insights into the structural and functional organization of neural tissues gained from the molecular and genetic analyses of these genes and their products [5].

Regulatory relationships of trk

  • Proteolytic cleavage of the Trunk precursor can activate Torso-dependent signaling, but the existence of cleaved Trunk has not yet been demonstrated in vivo for Drosophila [6].


  1. Similarities between trunk and spätzle, putative extracellular ligands specifying body pattern in Drosophila. Casanova, J., Furriols, M., McCormick, C.A., Struhl, G. Genes Dev. (1995) [Pubmed]
  2. A novel modular mosaic of cell adhesion motifs in the extracellular domains of the neurogenic trk and trkB tyrosine kinase receptors. Schneider, R., Schweiger, M. Oncogene (1991) [Pubmed]
  3. Neurotrophic activities of trk receptors conserved over 600 million years of evolution. Beck, G., Munno, D.W., Levy, Z., Dissel, H.M., Van-Minnen, J., Syed, N.I., Fainzilber, M. J. Neurobiol. (2004) [Pubmed]
  4. Dissecting the mechanism of torso receptor activation. Furriols, M., Casali, A., Casanova, J. Mech. Dev. (1998) [Pubmed]
  5. Proto-oncogenes and signaling processes in neural tissues. Sudol, M., Grant, S.G., Maisonpierre, P.C. Neurochem. Int. (1993) [Pubmed]
  6. The torso ligand, unmasked? Stein, D., Stevens, L.M. Sci. STKE (2001) [Pubmed]
WikiGenes - Universities