High impact information on trk

• Here we report that trunk (trk), a gene required for activity of the tor receptor, encodes a protein that resembles spz in several respects [1].
• Furthermore, the carboxy-terminal domain of trk has a similar arrangement of cysteines to that of spz [1].
• A novel modular mosaic of cell adhesion motifs in the extracellular domains of the neurogenic trk and trkB tyrosine kinase receptors [2].
• The trk family of receptor tyrosine kinases is crucial for neuronal survival in the vertebrate nervous system, however both C. elegans and Drosophila lack genes encoding trks or their ligands [3].
• However, it is not well understood how this signal is generated, although it is known to depend on the activity of many genes such as torso-like (tsl) and trunk (trk) [4].

Biological context of trk

• Using the trk, abl and src families of tyrosine kinase encoded proto-oncogenes, we discuss here new insights into the structural and functional organization of neural tissues gained from the molecular and genetic analyses of these genes and their products [5].

Regulatory relationships of trk

• Proteolytic cleavage of the Trunk precursor can activate Torso-dependent signaling, but the existence of cleaved Trunk has not yet been demonstrated in vivo for Drosophila [6].

References