Gene Review:
NTRK2 - neurotrophic tyrosine kinase, receptor,...
Homo sapiens
Synonyms:
BDNF/NT-3 growth factors receptor, GP145-TrkB, Neurotrophic tyrosine kinase receptor type 2, TRKB, Trk-B, ...
- Association of BDNF with restricting anorexia nervosa and minimum body mass index: a family-based association study of eight European populations. Ribasés, M., Gratacòs, M., Fernández-Aranda, F., Bellodi, L., Boni, C., Anderluh, M., Cristina Cavallini, M., Cellini, E., Di Bella, D., Erzegovesi, S., Foulon, C., Gabrovsek, M., Gorwood, P., Hebebrand, J., Hinney, A., Holliday, J., Hu, X., Karwautz, A., Kipman, A., Komel, R., Nacmias, B., Remschmidt, H., Ricca, V., Sorbi, S., Tomori, M., Wagner, G., Treasure, J., Collier, D.A., Estivill, X. Eur. J. Hum. Genet. (2005)
- The human gene for neurotrophic tyrosine kinase receptor type 2 (NTRK2) is located on chromosome 9 but is not the familial dysautonomia gene. Slaugenhaupt, S.A., Blumenfeld, A., Liebert, C.B., Mull, J., Lucente, D.E., Monahan, M., Breakefield, X.O., Maayan, C., Parada, L., Axelrod, F.B. Genomics (1995)
- Functional characterization of human NTRK2 mutations identified in patients with severe early-onset obesity. Gray, J., Yeo, G., Hung, C., Keogh, J., Clayton, P., Banerjee, K., McAulay, A., O'rahilly, S., Farooqi, I.S. International journal of obesity (2005) (2007)
- Localization of neurotrophins and their high-affinity receptors during human enteric nervous system development. Hoehner, J.C., Wester, T., Påhlman, S., Olsen, L. Gastroenterology (1996)
- Resistance to chemotherapy mediated by TrkB in neuroblastomas. Ho, R., Eggert, A., Hishiki, T., Minturn, J.E., Ikegaki, N., Foster, P., Camoratto, A.M., Evans, A.E., Brodeur, G.M. Cancer Res. (2002)
- Contribution of NTRK2 to the genetic susceptibility to anorexia nervosa, harm avoidance and minimum body mass index. Ribases, M., Gratacos, M., Badia, A., Jimenez, L., Solano, R., Vallejo, J., Fernandez-Aranda, F., Estivill, X. Mol. Psychiatry (2005)
- Association study of neurotrophic tyrosine kinase receptor type 2 (NTRK2) and childhood-onset mood disorders. Adams, J.H., Wigg, K.G., King, N., Burcescu, I., Vetró, A., Kiss, E., Baji, I., George, C.J., Kennedy, J.L., Kovacs, M., Barr, C.L. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2005)
- Reduced expression of the TrkB receptor in Huntington's disease mouse models and in human brain. Ginés, S., Bosch, M., Marco, S., Gavaldà, N., Díaz-Hernández, M., Lucas, J.J., Canals, J.M., Alberch, J. Eur. J. Neurosci. (2006)
- Association of Specific Haplotypes of Neurotrophic Tyrosine Kinase Receptor 2 Gene (NTRK2) with Vulnerability to Nicotine Dependence in African-Americans and European-Americans. Beuten, J., Ma, J.Z., Payne, T.J., Dupont, R.T., Lou, X.Y., Crews, K.M., Elston, R.C., Li, M.D. Biol. Psychiatry (2007)
- Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression. Eisch, A.J., Bolaños, C.A., de Wit, J., Simonak, R.D., Pudiak, C.M., Barrot, M., Verhaagen, J., Nestler, E.J. Biol. Psychiatry (2003)
- Neurotrophin-evoked depolarization requires the sodium channel Na(V)1.9. Blum, R., Kafitz, K.W., Konnerth, A. Nature (2002)
- Activity-dependent modulation of the BDNF receptor TrkB: mechanisms and implications. Nagappan, G., Lu, B. Trends Neurosci. (2005)
- BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Yano, H., Ninan, I., Zhang, H., Milner, T.A., Arancio, O., Chao, M.V. Nat. Neurosci. (2006)
- A de novo mutation affecting human TrkB associated with severe obesity and developmental delay. Yeo, G.S., Connie Hung, C.C., Rochford, J., Keogh, J., Gray, J., Sivaramakrishnan, S., O'Rahilly, S., Farooqi, I.S. Nat. Neurosci. (2004)
- Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Xu, B., Goulding, E.H., Zang, K., Cepoi, D., Cone, R.D., Jones, K.R., Tecott, L.H., Reichardt, L.F. Nat. Neurosci. (2003)
- Nicotine regulates SH-SY5Y neuroblastoma cell proliferation through the release of brain-derived neurotrophic factor. Serres, F., Carney, S.L. Brain Res. (2006)
- Regulation by nicotine of gpr51 and ntrk2 expression in various rat brain regions. Sun, D., Huang, W., Hwang, Y.Y., Zhang, Y., Zhang, Q., Li, M.D. Neuropsychopharmacology (2007)
- Identification of differentially methylated CpG islands in prostate cancer. Yamada, Y., Toyota, M., Hirokawa, Y., Suzuki, H., Takagi, A., Matsuzaki, T., Sugimura, Y., Yatani, R., Shiraishi, T., Watanabe, M. Int. J. Cancer (2004)
- Induction of TrkB by retinoic acid mediates biologic responsiveness to BDNF and differentiation of human neuroblastoma cells. Eukaryotic Signal Transduction Group. Kaplan, D.R., Matsumoto, K., Lucarelli, E., Thiele, C.J. Neuron (1993)
- Downregulation of Bim by brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from paclitaxel but not etoposide or cisplatin-induced cell death. Li, Z., Zhang, J., Liu, Z., Woo, C.W., Thiele, C.J. Cell Death Differ. (2007)
- Mutation analysis of NTRK2 and NTRK3, encoding 2 tyrosine kinase receptors, in sporadic human medullary thyroid carcinoma reveals novel sequence variants. Gimm, O., Dziema, H., Brown, J., de la Puente, A., Hoang-Vu, C., Dralle, H., Plass, C., Eng, C. Int. J. Cancer (2001)
- Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via phosphatidylinositol 3'-kinase pathway. Jaboin, J., Kim, C.J., Kaplan, D.R., Thiele, C.J. Cancer Res. (2002)
- Human and rat hepatic stellate cells express neurotrophins and neurotrophin receptors. Cassiman, D., Denef, C., Desmet, V.J., Roskams, T. Hepatology (2001)
- Cloning and expression of a novel neurotrophin, NT-7, from carp. Lai, K.O., Fu, W.Y., Ip, F.C., Ip, N.Y. Mol. Cell. Neurosci. (1998)
- Neurotrophin-4/5 and neurotrophin-3 are present within the human ovarian follicle but appear to have different paracrine/autocrine functions. Seifer, D.B., Feng, B., Shelden, R.M., Chen, S., Dreyfus, C.F. J. Clin. Endocrinol. Metab. (2002)
- Extracellular-regulated kinases and phosphatidylinositol 3-kinase are involved in brain-derived neurotrophic factor-mediated survival and neuritogenesis of the neuroblastoma cell line SH-SY5Y. Encinas, M., Iglesias, M., Llecha, N., Comella, J.X. J. Neurochem. (1999)
- Specific neurotrophin binding to leucine-rich motif peptides of TrkA and TrkB. Windisch, J.M., Auer, B., Marksteiner, R., Lang, M.E., Schneider, R. FEBS Lett. (1995)
- Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia. Hashimoto, T., Bergen, S.E., Nguyen, Q.L., Xu, B., Monteggia, L.M., Pierri, J.N., Sun, Z., Sampson, A.R., Lewis, D.A. J. Neurosci. (2005)
- A discrete domain of the human TrkB receptor defines the binding sites for BDNF and NT-4. Naylor, R.L., Robertson, A.G., Allen, S.J., Sessions, R.B., Clarke, A.R., Mason, G.G., Burston, J.J., Tyler, S.J., Wilcock, G.K., Dawbarn, D. Biochem. Biophys. Res. Commun. (2002)
- Analysis of tyrosine phosphorylation-dependent protein-protein interactions in TrkB-mediated intracellular signaling using modified yeast two-hybrid system. Yamada, M., Suzuki, K., Mizutani, M., Asada, A., Matozaki, T., Ikeuchi, T., Koizumi, S., Hatanaka, H. J. Biochem. (2001)
- Specificity in Trk receptor:neurotrophin interactions: the crystal structure of TrkB-d5 in complex with neurotrophin-4/5. Banfield, M.J., Naylor, R.L., Robertson, A.G., Allen, S.J., Dawbarn, D., Brady, R.L. Structure (Camb.) (2001)
- Basic helix-loop-helix proteins bind to TrkB and p21(Cip1) promoters linking differentiation and cell cycle arrest in neuroblastoma cells. Liu, Y., Encinas, M., Comella, J.X., Aldea, M., Gallego, C. Mol. Cell. Biol. (2004)
- BDNF and TrkB co-localize in CA1 neurons resistant to transient forebrain ischemia in the adult gerbil. Ferrer, I., Ballabriga, J., Martí, E., Pozas, E., Planas, A.M., Blasi, J. J. Neuropathol. Exp. Neurol. (1997)
- Brain-derived neurotrophic factor activation of TrkB induces vascular endothelial growth factor expression via hypoxia-inducible factor-1alpha in neuroblastoma cells. Nakamura, K., Martin, K.C., Jackson, J.K., Beppu, K., Woo, C.W., Thiele, C.J. Cancer Res. (2006)
- The protein tyrosine phosphatase, Shp2, is required for the complete activation of the RAS/MAPK pathway by brain-derived neurotrophic factor. Easton, J.B., Royer, A.R., Middlemas, D.S. J. Neurochem. (2006)
- Characterization and crystallization of recombinant human neurotrophin-4. Fandl, J.P., Tobkes, N.J., McDonald, N.Q., Hendrickson, W.A., Ryan, T.E., Nigam, S., Acheson, A., Cudny, H., Panayotatos, N. J. Biol. Chem. (1994)
- The neurotrophin receptor TrkB cooperates with c-Met in enhancing neuroblastoma invasiveness. Hecht, M., Schulte, J.H., Eggert, A., Wilting, J., Schweigerer, L. Carcinogenesis (2005)
- Microarray analysis reveals differential gene expression patterns and regulation of single target genes contributing to the opposing phenotype of TrkA- and TrkB-expressing neuroblastomas. Schulte, J.H., Schramm, A., Klein-Hitpass, L., Klenk, M., Wessels, H., Hauffa, B.P., Eils, J., Eils, R., Brodeur, G.M., Schweigerer, L., Havers, W., Eggert, A. Oncogene (2005)
- Expression of TrkA, TrkB and TrkC in human neuroblastomas. Brodeur, G.M., Nakagawara, A., Yamashiro, D.J., Ikegaki, N., Liu, X.G., Azar, C.G., Lee, C.P., Evans, A.E. J. Neurooncol. (1997)
- Tyrosine kinase inhibitor CEP-701 blocks the NTRK1/NGF receptor and limits the invasive capability of prostate cancer cells in vitro. Festuccia, C., Muzi, P., Gravina, G.L., Millimaggi, D., Speca, S., Dolo, V., Ricevuto, E., Vicentini, C., Bologna, M. Int. J. Oncol. (2007)
- Mapping of the tyrosine kinase receptors trkA (NTRK1), trkB (NTRK2) and trkC(NTRK3) to human chromosomes 1q22, 9q22 and 15q25 by fluorescence in situ hybridization. Valent, A., Danglot, G., Bernheim, A. Eur. J. Hum. Genet. (1997)
- Expression of functional TrkA receptor tyrosine kinase in the HMC-1 human mast cell line and in human mast cells. Tam, S.Y., Tsai, M., Yamaguchi, M., Yano, K., Butterfield, J.H., Galli, S.J. Blood (1997)
- Neurotrophin modulation of voltage-gated potassium channels in rat through TrkB receptors is time and sensory experience dependent. Tucker, K., Fadool, D.A. J. Physiol. (Lond.) (2002)