High impact information on tsl

• These results suggest that the tsl protein is the ligand that binds to the torso receptor [1].
• At early blastoderm stage, tsl protein forms a symmetrical concentration gradient at the poles on the surface of the devitellinized embryo [1].
• Moreover, mosaic analysis demonstrates that tsl expression is necessary only in subpopulations of follicle cells located at the poles of the oocyte [2].
• Here we describe torso-like (tsl), the sixth member of the terminal gene class, and show that it is unique among these genes in that its expression is required in the somatic follicle cells rather than in the germ line [2].
• Cell surface proteins Nasrat and Polehole stabilize the Torso-like extracellular determinant in Drosophila oogenesis [3].

Biological context of tsl

• Genetic mosaic analysis has shown that tsl is required during oogenesis in follicle cells at each end of the oocyte [4].
• Ectopic expression of tsl produced embryos with a phenotype similar to that resulting from constitutively active Tor alleles [4].
• A tsl strain, AUSTRIA 6-97, was constructed to follow the fate of aneuploid individuals during male-only production [5].
• The high-temperature treatment of eggs of mass-reared tsl genetic sexing strains in Mediterranean fruit fly, Ceratitis capitata (Wiedemann), during late embryogenesis (the low-high protocol) conserves more male flies than treatment during early embryogenesis [5].

Other interactions of tsl

• However, it is not well understood how this signal is generated, although it is known to depend on the activity of many genes such as torso-like (tsl) and trunk (trk) [6].
• Unexpectedly, the terminal pathway gene torso-like is required for Bcd-dependent transcription [7].

References