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Gene Review

TUBGCP4  -  tubulin, gamma complex associated protein 4

Homo sapiens

Synonyms: 76P, FLJ14797, GCP-4, GCP4, Gamma-ring complex protein 76 kDa, ...
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High impact information on 76P

  • Several pieces of evidence indicate that h76p is involved in microtubule nucleation [1].
  • (1) h76p is localized at the centrosome as demonstrated by immunofluorescence [1].
  • (5) h76p is necessary for aster nucleation by sperm basal bodies and recombinant h76p partially replaces endogenous 76p in oocyte extracts [1].
  • We identified three genes, gfh1+, mod21+, and mod22+, in a screen for fission yeast mutants affecting microtubule organization. gfh1+ is a previously characterized gamma-TuC protein weakly similar to human gamma-TuC subunit GCP4, whereas mod21+ is novel and shows weak similarity to human gamma-TuC subunit GCP5 [2].


  1. Human 76p: A new member of the gamma-tubulin-associated protein family. Fava, F., Raynaud-Messina, B., Leung-Tack, J., Mazzolini, L., Li, M., Guillemot, J.C., Cachot, D., Tollon, Y., Ferrara, P., Wright, M. J. Cell Biol. (1999) [Pubmed]
  2. Noncore Components of the Fission Yeast {gamma}-Tubulin Complex. Anders, A., Louren??o, P.C., Sawin, K.E. Mol. Biol. Cell (2006) [Pubmed]
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