Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Tehao - CG7121 gene product from transcript CG7121-RB

Drosophila melanogaster

Synonyms: CG7121, CT22017, Dmel\CG7121, Tho, Tl-5, ...

Luo, C. et al., Luna, C. et al., Luna, C. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Tehao

All three genes exhibited high levels of amino acid sequence similarity with Drosophila melanogaster (Dm)Toll1 and DmTehao (Toll5) [1].
Tehao functions in the Toll pathway in Drosophila melanogaster: possible roles in development and innate immunity [2].
In transiently transfected cells, Tehao activated both Dorsal and the transcription of endogenous drosomycin and metchnikowin genes [2].
In insects, Toll and two other related proteins, Tehao and 18-wheeler have been shown to participate in the activation of the innate immune responses to fungal and bacterial pathogens [3].

Regulatory relationships of Tehao

Remarkably, Tehao was found to activate Dorsal-dependent transcription in a synergistic manner with Toll, as well as Pelle in co-transfected cells [2].

References

Characterization of three Toll-like genes from mosquito Aedes aegypti. Luna, C., Hoa, N.T., Zhang, J., Kanzok, S.M., Brown, S.E., Imler, J.L., Knudson, D.L., Zheng, L. Insect Mol. Biol. (2003) [Pubmed]
Tehao functions in the Toll pathway in Drosophila melanogaster: possible roles in development and innate immunity. Luo, C., Shen, B., Manley, J.L., Zheng, L. Insect Mol. Biol. (2001) [Pubmed]
Characterization of four Toll related genes during development and immune responses in Anopheles gambiae. Luna, C., Wang, X., Huang, Y., Zhang, J., Zheng, L. Insect Biochem. Mol. Biol. (2002) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.