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Gene Review:

Mtk - Metchnikowin

Drosophila melanogaster

Synonyms: BcDNA:RH07954, CG8175, DIM 17, Dmel\CG8175, METCH, ...

Levashina, E.A. et al., Peng, J. et al., Park, S.Y. et al.

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Psychiatry related information on Mtk

Sex-peptide (SP), a male seminal peptide transferred during copulation, is the major agent eliciting transcription of Mtk and of other AMP genes [1].

High impact information on Mtk

Both pathways are needed for Mtk induction by SP [1].
Here we present evidence that induction of metchnikowin gene expression can be mediated either by the TOLL pathway or by the imd gene product [2].
Metchnikowin is a recently discovered proline-rich peptide from Drosophila with antibacterial and antifungal properties [2].
However, in Toll-deficient;imd double mutants, metchnikowin gene expression can no longer be detected after immune challenge [2].
Cloning of the metchnikowin gene revealed the presence in the 5' flanking region of several putative cis-regulatory motifs characterized in the promoters of insect immune genes: namely, Rel sites, GATA motifs, interferon consensus response elements and NF-IL6 response elements [2].

Biological context of Mtk

Establishment of transgenic fly lines in which the GFP reporter gene was placed under the control of 1.5 kb of metchnikowin gene upstream sequences indicates that this fragment is able to confer full immune inducibility and tissue specificity of expression on the transgene [2].

Other interactions of Mtk

Ectopic expression of Attacin A and Metchnikowin enhanced the survival of D. melanogaster upon V. cholerae infection [3].

References

Drosophila sex-peptide stimulates female innate immune system after mating via the Toll and Imd pathways. Peng, J., Zipperlen, P., Kubli, E. Curr. Biol. (2005) [Pubmed]
Two distinct pathways can control expression of the gene encoding the Drosophila antimicrobial peptide metchnikowin. Levashina, E.A., Ohresser, S., Lemaitre, B., Imler, J.L. J. Mol. Biol. (1998) [Pubmed]
Drosophila melanogaster is susceptible to Vibrio cholerae infection. Park, S.Y., Heo, Y.J., Kim, K.S., Cho, Y.H. Mol. Cells (2005) [Pubmed]

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