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Gene Review

Mtk  -  Metchnikowin

Drosophila melanogaster

Synonyms: BcDNA:RH07954, CG8175, DIM 17, Dmel\CG8175, METCH, ...
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Psychiatry related information on Mtk

  • Sex-peptide (SP), a male seminal peptide transferred during copulation, is the major agent eliciting transcription of Mtk and of other AMP genes [1].

High impact information on Mtk


Biological context of Mtk

  • Establishment of transgenic fly lines in which the GFP reporter gene was placed under the control of 1.5 kb of metchnikowin gene upstream sequences indicates that this fragment is able to confer full immune inducibility and tissue specificity of expression on the transgene [2].

Other interactions of Mtk

  • Ectopic expression of Attacin A and Metchnikowin enhanced the survival of D. melanogaster upon V. cholerae infection [3].


  1. Drosophila sex-peptide stimulates female innate immune system after mating via the Toll and Imd pathways. Peng, J., Zipperlen, P., Kubli, E. Curr. Biol. (2005) [Pubmed]
  2. Two distinct pathways can control expression of the gene encoding the Drosophila antimicrobial peptide metchnikowin. Levashina, E.A., Ohresser, S., Lemaitre, B., Imler, J.L. J. Mol. Biol. (1998) [Pubmed]
  3. Drosophila melanogaster is susceptible to Vibrio cholerae infection. Park, S.Y., Heo, Y.J., Kim, K.S., Cho, Y.H. Mol. Cells (2005) [Pubmed]
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