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Gene Review

Arpc1  -  Actin-related protein 2/3 complex, subunit 1

Drosophila melanogaster

Synonyms: 34Dd, ARC-P41, ARPC1, ARPC1/p41, Arc41, ...
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High impact information on Sop2

  • Biochemical analyses demonstrate that Sop2p is present in a complex which also contains the actin-related protein, Arp3p [1].
  • In addition, our results suggest that the Arpc1 subunit may have an additional function, independent of the rest of the Arp2/3 complex [2].
  • In vivo analysis of actin reorganization demonstrates that the arpc1 mutation does not prevent assembly of small actin caps but blocks cap expansion and furrow assembly as the cell cycle progresses through interphase [3].
  • In vitro phosphorylation analysis showed a direct phosphorylation of CLK by CaMK II and p42 MAPK [extracellular signal-regulated kinase (ERK) 2], suggesting that these kinases regulate CLK/CYC-dependent transcription by direct phosphorylation of CLK [4].

Analytical, diagnostic and therapeutic context of Sop2

  • Immunofluorescence studies reveal the presence of Sop2p in (i) punctate structures distributed throughout the cell, (ii) cables that extend the length of the cell, and (iii) a medial band in a small percentage of septating cells [1].


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