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ARP3  -  actin-related protein 3

Saccharomyces cerevisiae S288c

Synonyms: ACT4, Actin-like protein 3, Actin-like protein ARP3, Actin-related protein 3, J1760, ...
 
 
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High impact information on ARP3

 

Biological context of ARP3

 

Other interactions of ARP3

  • Two such factors have been characterized from yeasts and metazoans: the Arp2/3 complex, a complex of seven highly conserved subunits including two actin-related proteins (ARP2 and ARP3), and the FORMIN family of proteins [5].
  • Identification of ACT4, a novel essential actin-related gene in the yeast Saccharomyces cerevisiae [4].
 

Analytical, diagnostic and therapeutic context of ARP3

  • The Arp2/3 complex, first isolated from Acanthamoeba castellani by affinity chromatography on profilin, consists of seven polypeptides; two actin-related proteins, Arp2 and Arp3; and five apparently novel proteins, p40, p35, p19, p18, and p14 (Machesky et al., 1994) [6].

References

  1. Arp2/3 ATP hydrolysis-catalysed branch dissociation is critical for endocytic force generation. Martin, A.C., Welch, M.D., Drubin, D.G. Nat. Cell Biol. (2006) [Pubmed]
  2. Effects of Arp2 and Arp3 nucleotide-binding pocket mutations on Arp2/3 complex function. Martin, A.C., Xu, X.P., Rouiller, I., Kaksonen, M., Sun, Y., Belmont, L., Volkmann, N., Hanein, D., Welch, M., Drubin, D.G. J. Cell Biol. (2005) [Pubmed]
  3. Fission yeast Sop2p: a novel and evolutionarily conserved protein that interacts with Arp3p and modulates profilin function. Balasubramanian, M.K., Feoktistova, A., McCollum, D., Gould, K.L. EMBO J. (1996) [Pubmed]
  4. Identification of ACT4, a novel essential actin-related gene in the yeast Saccharomyces cerevisiae. Huang, M.E., Souciet, J.L., Chuat, J.C., Galibert, F. Yeast (1996) [Pubmed]
  5. The formin homology 1 domain modulates the actin nucleation and bundling activity of Arabidopsis FORMIN1. Michelot, A., Guérin, C., Huang, S., Ingouff, M., Richard, S., Rodiuc, N., Staiger, C.J., Blanchoin, L. Plant Cell (2005) [Pubmed]
  6. Structure, subunit topology, and actin-binding activity of the Arp2/3 complex from Acanthamoeba. Mullins, R.D., Stafford, W.F., Pollard, T.D. J. Cell Biol. (1997) [Pubmed]
 
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