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Gene Review

Top3alpha  -  Topoisomerase 3alpha

Drosophila melanogaster

Synonyms: CG10123, DNA topoisomerase 3-alpha, DNA topoisomerase III alpha, DmTop3alpha, Dmel\CG10123, ...
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High impact information on Top3alpha

  • Previous biochemical studies of the BLM gene product have shown its ability in conjunction with topoisomerase IIIalpha to resolve double Holliday structures through a process called "dissolution." This process could prevent crossing over during repair of double-strand breaks [1].
  • Whereas this mutation can be rescued by a Top3alpha transgene, ubiquitous overexpression of D. melanogaster topo IIIbeta cannot rescue this allele [2].
  • A mutant allele of the Top3alpha gene, Top3alpha191, was isolated through imprecise excision mutagenesis of an existing P-element inserted in the first intron of the gene [2].


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