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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Top3alpha  -  Topoisomerase 3alpha

Drosophila melanogaster

Synonyms: CG10123, DNA topoisomerase 3-alpha, DNA topoisomerase III alpha, DmTop3alpha, Dmel\CG10123, ...
 
 
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High impact information on Top3alpha

  • Previous biochemical studies of the BLM gene product have shown its ability in conjunction with topoisomerase IIIalpha to resolve double Holliday structures through a process called "dissolution." This process could prevent crossing over during repair of double-strand breaks [1].
  • Whereas this mutation can be rescued by a Top3alpha transgene, ubiquitous overexpression of D. melanogaster topo IIIbeta cannot rescue this allele [2].
  • A mutant allele of the Top3alpha gene, Top3alpha191, was isolated through imprecise excision mutagenesis of an existing P-element inserted in the first intron of the gene [2].

References

  1. Template disruptions and failure of double Holliday junction dissolution during double-strand break repair in Drosophila BLM mutants. Johnson-Schlitz, D., Engels, W.R. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. Drosophila melanogaster topoisomerase IIIalpha preferentially relaxes a positively or negatively supercoiled bubble substrate and is essential during development. Plank, J.L., Chu, S.H., Pohlhaus, J.R., Wilson-Sali, T., Hsieh, T.S. J. Biol. Chem. (2005) [Pubmed]
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