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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Crossing Over, Genetic

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Disease relevance of Crossing Over, Genetic


High impact information on Crossing Over, Genetic


Chemical compound and disease context of Crossing Over, Genetic


Biological context of Crossing Over, Genetic


Anatomical context of Crossing Over, Genetic

  • Ercc1 was expressed at a high level in the testis and the highest levels of Ercc1 protein occurred in germ cells following meiotic crossing over [16].
  • A Y + ve group of ten patients exhibit sex reversal as the result of transfer of the distal end of the short arm of the Y chromosome, including testis determining factors, to the short arm of one X-chromosome, presumably by accidental crossing-over in paternal meiosis [17].
  • These pairs were inherited with chimpanzee leukocyte antigen types C2 and BF variants without detectable crossing-over [18].
  • This would allow for crossing over of impulses from one nerve fiber to another and interaction between afferent and efferent axons, analogous to the situation of bare, uninsulated electrical wires plac[19]
  • Climbing fibers showed a characteristic crossing-over bifurcation pattern in the white matter and in the three-layer structure of cerebellar cortex, formation of tendril collaterals in the granular layer, topographical relationship with Purkinje cell soma and retrograde collaterals in the molecular layer [20].

Associations of Crossing Over, Genetic with chemical compounds


Gene context of Crossing Over, Genetic

  • Analysis of an mlh1 msh4 double mutant suggests that both genes act in the same pathway to promote crossing-over [26].
  • Absence of either of the meiosis-specific mutS homologs Msh4 or Msh5 results in a similar reduction in crossing-over [26].
  • Conversely, crossing-over in the mlh3 mutant is reduced to approximately 70% of wild-type levels but correction of heteroduplex is normal [27].
  • In a mlh2 mutant, crossing-over is normal and postmeiotic segregation is not observed but non-Mendelian segregation is elevated and altered with respect to parity [27].
  • The residual repair events in rad51 mutants were more frequently associated with crossing over than was observed in the wild-type strain, suggesting that the mechanisms for RAD51-dependent and RAD51-independent events are different [28].

Analytical, diagnostic and therapeutic context of Crossing Over, Genetic

  • Restriction mapping and allele-specific oligonucleotide hybridization grossly defined the third intron as the probable crossing-over site and showed that MiV and MiV(J.L.) genes are arranged in the same 5' alpha-delta 3' frame whereas Sta gene is in a reciprocal 5'delta-alpha 3' configuration [29].


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  2. Unequal exchange at the Charcot-Marie-Tooth disease type 1A recombination hot-spot is not elevated above the genome average rate. Han, L.L., Keller, M.P., Navidi, W., Chance, P.F., Arnheim, N. Hum. Mol. Genet. (2000) [Pubmed]
  3. Unequal crossing-over between aldosterone synthase and 11beta-hydroxylase genes causes congenital adrenal hyperplasia. Hampf, M., Dao, N.T., Hoan, N.T., Bernhardt, R. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  4. mei-P22 encodes a chromosome-associated protein required for the initiation of meiotic recombination in Drosophila melanogaster. Liu, H., Jang, J.K., Kato, N., McKim, K.S. Genetics (2002) [Pubmed]
  5. 5-fluorouracil and folinic acid-induced mucositis: no effect of oral glutamine supplementation. Jebb, S.A., Osborne, R.J., Maughan, T.S., Mohideen, N., Mack, P., Mort, D., Shelley, M.D., Elia, M. Br. J. Cancer (1994) [Pubmed]
  6. A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair. Tishkoff, D.X., Filosi, N., Gaida, G.M., Kolodner, R.D. Cell (1997) [Pubmed]
  7. Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III. Simon, D.B., Bindra, R.S., Mansfield, T.A., Nelson-Williams, C., Mendonca, E., Stone, R., Schurman, S., Nayir, A., Alpay, H., Bakkaloglu, A., Rodriguez-Soriano, J., Morales, J.M., Sanjad, S.A., Taylor, C.M., Pilz, D., Brem, A., Trachtman, H., Griswold, W., Richard, G.A., John, E., Lifton, R.P. Nat. Genet. (1997) [Pubmed]
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  9. The HOP1 gene encodes a meiosis-specific component of yeast chromosomes. Hollingsworth, N.M., Goetsch, L., Byers, B. Cell (1990) [Pubmed]
  10. Meiotic gene conversion and crossing over: their relationship to each other and to chromosome synapsis and segregation. Engebrecht, J., Hirsch, J., Roeder, G.S. Cell (1990) [Pubmed]
  11. Effect of spermine on number of crossing-over events in post-conjugational recombination in Escherichia coli K-12. Białkowska-Hobrzańska, H. Acta Microbiol. Pol. (1979) [Pubmed]
  12. A sex chromosome rearrangement in a human XX male caused by Alu-Alu recombination. Rouyer, F., Simmler, M.C., Page, D.C., Weissenbach, J. Cell (1987) [Pubmed]
  13. Meitoic crossing-over between the X and Y chromosomes of male mice carrying the sex-reversing (Sxr) factor. Evans, E.P., Burtenshaw, M.D., Cattanach, B.M. Nature (1982) [Pubmed]
  14. Ndj1p, a meiotic telomere protein required for normal chromosome synapsis and segregation in yeast. Conrad, M.N., Dominguez, A.M., Dresser, M.E. Science (1997) [Pubmed]
  15. Meiotic synapsis in the absence of recombination. McKim, K.S., Green-Marroquin, B.L., Sekelsky, J.J., Chin, G., Steinberg, C., Khodosh, R., Hawley, R.S. Science (1998) [Pubmed]
  16. DNA repair gene Ercc1 is essential for normal spermatogenesis and oogenesis and for functional integrity of germ cell DNA in the mouse. Hsia, K.T., Millar, M.R., King, S., Selfridge, J., Redhead, N.J., Melton, D.W., Saunders, P.T. Development (2003) [Pubmed]
  17. Genotype-phenotype correlations in XX males and their bearing on current theories of sex determination. Ferguson-Smith, M.A., Cooke, A., Affara, N.A., Boyd, E., Tolmie, J.L. Hum. Genet. (1990) [Pubmed]
  18. There are two C4 genetic loci and a null allele in the chimpanzee. Granados, J., Awdeh, Z.L., Chen, J.H., Giles, C.M., Balner, H., Yunis, E.J., Alper, C.A. Immunogenetics (1987) [Pubmed]
  19. Postfacial palsy phenomena: faulty nerve regeneration or ephaptic transmission? Sadjadpour, K. Brain Res. (1975) [Pubmed]
  20. Field emission scanning electron microscopy and freeze-fracture transmission electron microscopy of mouse cerebellar synaptic contacts. Castejón, O.J., Apkarian, R.P., Castejón, H.V., Alvarado, M.V. J. Submicrosc. Cytol. Pathol. (2001) [Pubmed]
  21. Polyalanine expansion in synpolydactyly might result from unequal crossing-over of HOXD13. Warren, S.T. Science (1997) [Pubmed]
  22. Genetic effects of impure and pure saccharin in yeast. Moore, C.W., Schmick, A. Science (1979) [Pubmed]
  23. Trial of cyclosporin in corticosteroid-dependent chronic severe asthma. Alexander, A.G., Barnes, N.C., Kay, A.B. Lancet (1992) [Pubmed]
  24. Cisplatin increases meiotic crossing-over in mice. Hanneman, W.H., Legare, M.E., Sweeney, S., Schimenti, J.C. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  25. Somatic nonhomologous crossing-over between neuropeptide genes in rat hypothalamic neurons. Mohr, E., Peters, A., Morris, J.F., Richter, D. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  26. Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosis. Hunter, N., Borts, R.H. Genes Dev. (1997) [Pubmed]
  27. Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction. Wang, T.F., Kleckner, N., Hunter, N. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  28. RAD51 is required for the repair of plasmid double-stranded DNA gaps from either plasmid or chromosomal templates. Bärtsch, S., Kang, L.E., Symington, L.S. Mol. Cell. Biol. (2000) [Pubmed]
  29. Identification of recombination events resulting in three hybrid genes encoding human MiV, MiV(J.L.), and Sta glycophorins. Huang, C.H., Blumenfeld, O.O. Blood (1991) [Pubmed]
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