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Gene Review

ANKRD37  -  ankyrin repeat domain 37

Homo sapiens

Synonyms: Ankyrin repeat domain-containing protein 37, LPR2BP, Low-density lipoprotein receptor-related protein 2-binding protein, Lrp2bp, hLrp2bp
 
 
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Disease relevance of ANKRD37

 

High impact information on ANKRD37

  • The hLrp2bp gene was located in chromosome 4q35 and the conserved ankyrin repeat domains were located between amino acid residues 10 and 116 [1].
  • ANKRD37 is a direct target of transcription factor HIF-1 and is highly induced in hypoxia [2]

References

  1. Molecular cloning and characterization of a novel human gene containing 4 ankyrin repeat domains. Li, J., Ji, C., Zheng, H., Fei, X., Zheng, M., Dai, J., Gu, S., Xie, Y., Mao, Y. Cell. Mol. Biol. Lett. (2005) [Pubmed]
  2. An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia. Benita, Y., Kikuchi, H., Smith, A.D., Zhang, M.Q., Chung, D.C., Xavier, R.J. Nucleic. Acids. Res. (2009) [Pubmed]
 
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