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Gene Review:

IGL - immunoglobulin lambda locus

Homo sapiens

Synonyms: IGL@, IGLC6

McDermid, H.E. et al., Chuchana, P. et al., Moraes Junta, C. et al., Zeidler, R. et al., Benjes, S.M. et al., et al.

Benjes, Morris,

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Disease relevance of IGL@

The variant translocation t(8;22) in Burkitt's lymphoma (BL) cells joins band q24 of chromosome 8 distal to the proto-oncogene MYC to the immunoglobulin lambda locus [1].
A long-range restriction map of the region between the immunoglobulin lambda locus and the Ewing sarcoma breakpoint has been constructed using the rare-cutting enzymes NotI, NruI, AscI, and BsiWI [2].

High impact information on IGL@

A novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NF kappa B [3].
Haplotypes were defined in the human immunoglobulin lambda locus by using three probes--V lambda VII, V lambda A, and V lambda I--hybridized to BamHI, KpnI, EcoRI, and HindIII digests [4].
Previous molecular studies had established that the 3' BCR had recombined at a novel site within the variable region of the immunoglobulin lambda locus ( IGL) [5].
The human immunoglobulin lambda locus ( IGL) is mapped at Chromosome 22q11.2, spanning about 1 Mb of DNA, and directs the synthesis of lambda-type immunoglobulin light chains [6].
Genomic organisation of 34 kb of the human immunoglobulin lambda locus (IGLV): restriction map and sequences of new V lambda III genes [7].

References

Breakpoints of Burkitt's lymphoma t(8;22) translocations map within a distance of 300 kb downstream of MYC. Zeidler, R., Joos, S., Delecluse, H.J., Klobeck, G., Vuillaume, M., Lenoir, G.M., Bornkamm, G.W., Lipp, M. Genes Chromosomes Cancer (1994) [Pubmed]
Long-range restriction map of human chromosome 22q11-22q12 between the lambda immunoglobulin locus and the Ewing sarcoma breakpoint. McDermid, H.E., Budarf, M.L., Emanuel, B.S. Genomics (1993) [Pubmed]
A novel enhancer in the immunoglobulin lambda locus is duplicated and functionally independent of NF kappa B. Hagman, J., Rudin, C.M., Haasch, D., Chaplin, D., Storb, U. Genes Dev. (1990) [Pubmed]
Haplotypes of the human immunoglobulin lambda IGLV7S1 and IGLV1S1 genes defined by restriction-site polymorphism and insertion/deletion of a 6-kb DNA fragment. Chuchana, P., Frippiat, J.P., Blancher, A., Lefranc, G., Lefranc, M.P. Am. J. Hum. Genet. (1993) [Pubmed]
A full-length and potentially active LINE element is integrated polymorphically within the IGL locus in a genomically unstable region of chromosome 22. Benjes, S.M., Morris, C.M. Hum. Genet. (2001) [Pubmed]
Genomic EcoRI polymorphism and cosmid sequencing reveal an insertion/deletion and a new IGLV5 allele in the human immunoglobulin lambda variable locus (22q11.2/IGLV). Moraes Junta, C., Passos, G.A. Immunogenetics (2003) [Pubmed]
Genomic organisation of 34 kb of the human immunoglobulin lambda locus (IGLV): restriction map and sequences of new V lambda III genes. Frippiat, J.P., Lefranc, M.P. Mol. Immunol. (1994) [Pubmed]

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