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Gene Review:

LILRA5 - leukocyte immunoglobulin-like receptor,...

Homo sapiens

Synonyms: CD85, CD85 antigen-like family member F, CD85F, CD85f, ILT-11, ...

Shiroishi, M. et al., Borges, L. et al., Hahtola, S. et al.

Borges, Kubin, Kuhlman,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of LILRA5

In both Sezary syndrome and mycosis fungoides blood samples, the S100P and LIR9 gene expression was up-regulated [1].

High impact information on LILRA5

LIR9 is mostly expressed in myeloid cells, including monocytes and neutrophils [2].
The transmembrane forms of LIR9 contain a short cytoplasmic domain and a charged arginine residue within the transmembrane region that is likely to mediate its association with another coreceptor [2].
Here we report the crystal structure of the extracellular domain of LILRA5, which is an activating Group 2 LILR expressed on monocytes and neutrophils [3].
Crystal structure of the human monocyte-activating receptor, "Group 2" leukocyte Ig-like receptor A5 (LILRA5/LIR9/ILT11) [3].

Analytical, diagnostic and therapeutic context of LILRA5

Consistently, the surface plasmon resonance and flow cytometric analyses demonstrated that LILRA5 exhibited no affinities to all tested MHCIs [3].

References

Th1 response and cytotoxicity genes are down-regulated in cutaneous T-cell lymphoma. Hahtola, S., Tuomela, S., Elo, L., Häkkinen, T., Karenko, L., Nedoszytko, B., Heikkilä, H., Saarialho-Kere, U., Roszkiewicz, J., Aittokallio, T., Lahesmaa, R., Ranki, A. Clin. Cancer Res. (2006) [Pubmed]
LIR9, an immunoglobulin-superfamily-activating receptor, is expressed as a transmembrane and as a secreted molecule. Borges, L., Kubin, M., Kuhlman, T. Blood (2003) [Pubmed]
Crystal structure of the human monocyte-activating receptor, "Group 2" leukocyte Ig-like receptor A5 (LILRA5/LIR9/ILT11). Shiroishi, M., Kajikawa, M., Kuroki, K., Ose, T., Kohda, D., Maenaka, K. J. Biol. Chem. (2006) [Pubmed]

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LILRA5	Canis lupus familiaris
Lilra5	Mus musculus
LILRA5	Pan troglodytes
Lilra5	Rattus norvegicus

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