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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

deg-3  -  Protein DEG-3

Caenorhabditis elegans

 
 
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High impact information on deg-3

  • The deg-3 gene from the nematode Caenorhabditis elegans encodes an alpha subunit of a nicotinic acetylcholine receptor that was first identified by a dominant allele, u662, which produced neuronal degeneration [1].
  • Because deg-3 cDNAs contain the SL2 trans-spliced leader, we suggested that deg-3 was transcribed as part of a C. elegans operon [1].
  • Characterization of the deg-3/des-2 receptor: a nicotinic acetylcholine receptor that mutates to cause neuronal degeneration [2].
  • This localization is in agreement with a role for this receptor in chemosensation of choline, as inferred from a defect in chemotaxis for choline seen in deg-3 mutants [2].

References

  1. Two functionally dependent acetylcholine subunits are encoded in a single Caenorhabditis elegans operon. Treinin, M., Gillo, B., Liebman, L., Chalfie, M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. Characterization of the deg-3/des-2 receptor: a nicotinic acetylcholine receptor that mutates to cause neuronal degeneration. Yassin, L., Gillo, B., Kahan, T., Halevi, S., Eshel, M., Treinin, M. Mol. Cell. Neurosci. (2001) [Pubmed]
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