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Gene Review

ceh-20  -  Protein CEH-20

Caenorhabditis elegans

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High impact information on ceh-20

  • We show here that in the P11 lineage, a complex between MAB-5 and the Pbx homolog CEH-20 directly regulates transcription of the BH3 domain gene egl-1 to initiate programmed cell death; in the P12 lineage, mab-5 and ceh-20 apparently act indirectly to initiate programmed cell death [1].
  • In this study, we have investigated the role of ceh-20, the C. elegans ortholog of the HOX co-factor Extradenticle (Exd/Pbx), and unc-62, the C. elegans ortholog of Homothorax (Hth/Meis/Prep), in two processes that are regulated by Hox gene lin-39: cell migration and vulva formation [2].
  • Thus, in this process, too, ceh-20 and unc-62 are likely to have functions that are independent of lin-39 [2].
  • To our knowledge, ceh-20 and unc-62 are the only genes that have been implicated in the mig-13 pathway [2].
  • We find that ceh-20 and unc-62 are also required for several steps in vulva development [2].

Biological context of ceh-20


Anatomical context of ceh-20

  • We investigated the role of the C. elegans Hox cluster and of the exd ortholog ceh-20 in patterning of the postembryonic mesoderm [3].

Other interactions of ceh-20

  • We show that important features of comma-stage expression depend on an autoregulatory input that requires ceh-13 and ceh-20 functions [4].


  1. Direct regulation of egl-1 and of programmed cell death by the Hox protein MAB-5 and by CEH-20, a C. elegans homolog of Pbx1. Liu, H., Strauss, T.J., Potts, M.B., Cameron, S. Development (2006) [Pubmed]
  2. The roles of two C. elegans HOX co-factor orthologs in cell migration and vulva development. Yang, L., Sym, M., Kenyon, C. Development (2005) [Pubmed]
  3. Overlapping roles of two Hox genes and the exd ortholog ceh-20 in diversification of the C. elegans postembryonic mesoderm. Liu, J., Fire, A. Development (2000) [Pubmed]
  4. Conserved regulation of the Caenorhabditis elegans labial/Hox1 gene ceh-13. Streit, A., Kohler, R., Marty, T., Belfiore, M., Takacs-Vellai, K., Vigano, M.A., Schnabel, R., Affolter, M., Müller, F. Dev. Biol. (2002) [Pubmed]
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