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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

ceh-13  -  Protein CEH-13

Caenorhabditis elegans

 
 
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High impact information on ceh-13

  • The only other Hox gene essential for embryogenesis is the labial/Hox1 homolog ceh-13, required for more anterior patterning [Brunschwig, K., Wittmann, C., Schnabel, R., Burglin, T. R., Tobler, H. & Muller, F. (1999) Development (Cambridge, U.K.) 126, 1537-1546] [1].
  • By transposon-mediated mutagenesis, we isolated a zygotic recessive ceh-13 loss-of-function allele, sw1, that exhibits an embryonic sublethal phenotype [2].
  • The expression of the C. elegans labial-like Hox gene ceh-13 during early embryogenesis relies on cell fate and on anteroposterior cell polarity [3].
  • As ceh-13 belongs to the labial class of homeoboxes, we conclude that, at the time when the nematode lineage diverged from the myriapod-insect and the vertebrate lineages, the duplication which led to the Antp and the labial families of homeoboxes had already taken place [4].
  • Hox genes are transcriptional regulators of metazoan body regionalization along the anteroposterior axis that act by specifying positional identity in differentiating cells. ceh-13, the labial orthologue in Caenorhabditis elegans, is expressed both during embryogenesis and post- embryonic development [5].
 

Biological context of ceh-13

 

Other interactions of ceh-13

  • We show that important features of comma-stage expression depend on an autoregulatory input that requires ceh-13 and ceh-20 functions [6].

References

  1. Caenorhabditis elegans embryonic axial patterning requires two recently discovered posterior-group Hox genes. Van Auken, K., Weaver, D.C., Edgar, L.G., Wood, W.B. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. Anterior organization of the Caenorhabditis elegans embryo by the labial-like Hox gene ceh-13. Brunschwig, K., Wittmann, C., Schnabel, R., Bürglin, T.R., Tobler, H., Müller, F. Development (1999) [Pubmed]
  3. The expression of the C. elegans labial-like Hox gene ceh-13 during early embryogenesis relies on cell fate and on anteroposterior cell polarity. Wittmann, C., Bossinger, O., Goldstein, B., Fleischmann, M., Kohler, R., Brunschwig, K., Tobler, H., Müller, F. Development (1997) [Pubmed]
  4. Cloning and analysis of three new homeobox genes from the nematode Caenorhabditis elegans. Schaller, D., Wittmann, C., Spicher, A., Müller, F., Tobler, H. Nucleic Acids Res. (1990) [Pubmed]
  5. Expression of the C. elegans labial orthologue ceh-13 during male tail morphogenesis. Stoyanov, C.N., Fleischmann, M., Suzuki, Y., Tapparel, N., Gautron, F., Streit, A., Wood, W.B., Müller, F. Dev. Biol. (2003) [Pubmed]
  6. Conserved regulation of the Caenorhabditis elegans labial/Hox1 gene ceh-13. Streit, A., Kohler, R., Marty, T., Belfiore, M., Takacs-Vellai, K., Vigano, M.A., Schnabel, R., Affolter, M., Müller, F. Dev. Biol. (2002) [Pubmed]
 
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