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Gene Review

Cul1  -  Cullin 1

Drosophila melanogaster

Synonyms: CG1877, CUL1, Cul-1, Cul1[Ex], Cullin homolog 1, ...
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High impact information on lin19

  • We found that Nedd8 modifies Cul1 in Drosophila [1].
  • In posterior cells, Ci degradation is controlled by a mechanism that requires the activity of Cul3, another member of the Cullin family [1].
  • The ubiquitin-like protein, Nedd8, covalently modifies members of the Cullin family [1].
  • These complexes are composed of three constant polypeptides--Skp1, Cullin1/3 and Roc1/Rbx1--and a fourth variable adapter, the F-box protein [2].
  • We show that Encore physically interacts with the proteasome, Cul1 and Cyclin E [3].

Biological context of lin19

  • Metal chelators and point mutations within JAMM abolished CSN-dependent cleavage of Nedd8 from Cul1, yet had little effect on CSN complex assembly [4].
  • We propose that in encore mutant germaria the proteolysis machinery is less efficient and, in addition, reduced association of Cul1 and S1 with the fusome may compromise Cyclin E destruction and consequently promote an extra round of mitosis [3].

Regulatory relationships of lin19

  • We propose that while Nedd8 promotes cullin activation through neddylation, neddylation also renders cullins unstable [5].

Other interactions of lin19

  • Targeted disruption of Drosophila Roc1b reveals functional differences in the Roc subunit of Cullin-dependent E3 ubiquitin ligases [6].
  • The association of Cul1, phosphorylated Cyclin E and the proteasome 19S-RP subunit S1 with the fusome is affected in encore mutant germaria [3].


  1. Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development. Ou, C.Y., Lin, Y.F., Chen, Y.J., Chien, C.T. Genes Dev. (2002) [Pubmed]
  2. Multiple roles of the F-box protein Slimb in Drosophila egg chamber development. Muzzopappa, M., Wappner, P. Development (2005) [Pubmed]
  3. Encore facilitates SCF-Ubiquitin-proteasome-dependent proteolysis during Drosophila oogenesis. Ohlmeyer, J.T., Schüpbach, T. Development (2003) [Pubmed]
  4. Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Cope, G.A., Suh, G.S., Aravind, L., Schwarz, S.E., Zipursky, S.L., Koonin, E.V., Deshaies, R.J. Science (2002) [Pubmed]
  5. Neddylation and deneddylation regulate Cul1 and Cul3 protein accumulation. Wu, J.T., Lin, H.C., Hu, Y.C., Chien, C.T. Nat. Cell Biol. (2005) [Pubmed]
  6. Targeted disruption of Drosophila Roc1b reveals functional differences in the Roc subunit of Cullin-dependent E3 ubiquitin ligases. Donaldson, T.D., Noureddine, M.A., Reynolds, P.J., Bradford, W., Duronio, R.J. Mol. Biol. Cell (2004) [Pubmed]
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