The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CycE  -  Cyclin E

Drosophila melanogaster

Synonyms: 3938, BG:DS07108.3, CDI7, CG3938, CYCE, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CycE

  • Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer [1].

Psychiatry related information on CycE


High impact information on CycE

  • Yorkie is known to activate Cyclin E (CycE) and the apoptosis inhibitor DIAP1 [3].
  • Hpo phosphorylates and activates Wts, which in turn, through unknown mechanisms, negatively regulates the transcription of cell-cycle and cell-death regulators such as cycE and diap1 [4].
  • Loss of hpo results in elevated transcription of the cell cycle regulator cyclin E and the cell-death inhibitor diap1, leading to increased proliferation and reduced apoptosis [5].
  • Ras upregulated the growth driver dMyc, and both Ras and dMyc increased levels of cyclin E posttranscriptionally [6].
  • We propose that Ras primarily promotes growth and that growth is coupled to G1/S progression via cyclin E. Interestingly, upregulation of growth by Ras did not deregulate G2/M progression or a developmentally regulated cell cycle exit [6].

Biological context of CycE

  • However, other components of the cell cycle seem to have a minor role in this process, suggesting a critical role for CycE in regulating cell fate in segment-specific neural lineages [7].
  • Genetic studies have shown that cyclin E and dE2F are critical regulators of S-phase entry during Drosophila embryogenesis [8].
  • We find that phosphorylation and degradation of Dup protein at G1/S requires cyclin E/CDK2 [9].
  • In higher eukaryotes, cyclin E is thought to control the progression from G1 into S phase of the cell cycle by associating as a regulatory subunit with cdk2 [10].
  • Analysis of a Drosophila cyclin E hypomorphic mutation suggests a novel role for cyclin E in cell proliferation control during eye imaginal disc development [11].

Anatomical context of CycE

  • Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines [12].
  • Drosophila skpA, a component of SCF ubiquitin ligases, regulates centrosome duplication independently of cyclin E accumulation [13].
  • CycE protein still cycles in cycE01672 germ-line cysts but at reduced levels, and it is found throughout a longer fraction of the cell cycle [14].
  • CycE specifies neuronal fate within neuroblast lineages by acting upstream of glial factors (prospero and glial cell missing), whereby levels of CycE are controlled by homeotic genes, the master control genes regulating segment specific development [15].
  • We suggest that Cyclin E also acts negatively to inhibit refiring of most origins within a cycle, and that specific factors at chorion origins allow them to escape this negative rereplication control [16].

Physical interactions of CycE


Regulatory relationships of CycE


Other interactions of CycE

  • Dup is phosphorylated by cyclin-E/Cdk2, but this direct phosphorylation was not sufficient to explain the rapid destruction of Dup at G1-S [24].
  • CycE, which is asymmetrically expressed after the first division of NB6-4t, functions upstream of pros and gcm to specify the neuronal sublineage [7].
  • Because archipelago can also regulate Cyclin E levels and Notch activity, these results indicate how a single F box protein can be responsible for the degradation of key components of multiple pathways that control growth and cell cycle progression [25].
  • Neither cyclin E nor E2F expression can phenocopy ana mutations, indicating that arrest caused by lack of Trol is different from Ana-mediated arrest [26].
  • They specify the NB6-4a lineage by down-regulating levels of the G1 cyclin, DmCycE (CycE) [7].

Analytical, diagnostic and therapeutic context of CycE


  1. Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer. Eder, A.M., Sui, X., Rosen, D.G., Nolden, L.K., Cheng, K.W., Lahad, J.P., Kango-Singh, M., Lu, K.H., Warneke, C.L., Atkinson, E.N., Bedrosian, I., Keyomarsi, K., Kuo, W.L., Gray, J.W., Yin, J.C., Liu, J., Halder, G., Mills, G.B. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Cyclin E at the centre of an identity crisis. Chia, W., Prokopenko, S.N. Nat. Cell Biol. (2005) [Pubmed]
  3. The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila. Thompson, B.J., Cohen, S.M. Cell (2006) [Pubmed]
  4. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Huang, J., Wu, S., Barrera, J., Matthews, K., Pan, D. Cell (2005) [Pubmed]
  5. hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Wu, S., Huang, J., Dong, J., Pan, D. Cell (2003) [Pubmed]
  6. Ras1 promotes cellular growth in the Drosophila wing. Prober, D.A., Edgar, B.A. Cell (2000) [Pubmed]
  7. A critical role for cyclin E in cell fate determination in the central nervous system of Drosophila melanogaster. Berger, C., Pallavi, S.K., Prasad, M., Shashidhara, L.S., Technau, G.M. Nat. Cell Biol. (2005) [Pubmed]
  8. RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Du, W., Vidal, M., Xie, J.E., Dyson, N. Genes Dev. (1996) [Pubmed]
  9. Drosophila double-parked is sufficient to induce re-replication during development and is regulated by cyclin E/CDK2. Thomer, M., May, N.R., Aggarwal, B.D., Kwok, G., Calvi, B.R. Development (2004) [Pubmed]
  10. A screen for modifiers of cyclin E function in Drosophila melanogaster identifies Cdk2 mutations, revealing the insignificance of putative phosphorylation sites in Cdk2. Lane, M.E., Elend, M., Heidmann, D., Herr, A., Marzodko, S., Herzig, A., Lehner, C.F. Genetics (2000) [Pubmed]
  11. Analysis of a Drosophila cyclin E hypomorphic mutation suggests a novel role for cyclin E in cell proliferation control during eye imaginal disc development. Secombe, J., Pispa, J., Saint, R., Richardson, H. Genetics (1998) [Pubmed]
  12. Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines. Moberg, K.H., Bell, D.W., Wahrer, D.C., Haber, D.A., Hariharan, I.K. Nature (2001) [Pubmed]
  13. Drosophila skpA, a component of SCF ubiquitin ligases, regulates centrosome duplication independently of cyclin E accumulation. Murphy, T.D. J. Cell. Sci. (2003) [Pubmed]
  14. The Drosophila endocycle is controlled by Cyclin E and lacks a checkpoint ensuring S-phase completion. Lilly, M.A., Spradling, A.C. Genes Dev. (1996) [Pubmed]
  15. Cyclin E acts under the control of Hox-genes as a cell fate determinant in the developing central nervous system. Berger, C., Pallavi, S.K., Prasad, M., Shashidhara, L.S., Technau, G.M. Cell Cycle (2005) [Pubmed]
  16. Cell cycle control of chorion gene amplification. Calvi, B.R., Lilly, M.A., Spradling, A.C. Genes Dev. (1998) [Pubmed]
  17. Critical role of active repression by E2F and Rb proteins in endoreplication during Drosophila development. Weng, L., Zhu, C., Xu, J., Du, W. EMBO J. (2003) [Pubmed]
  18. Drosophila cyclin E interacts with components of the Brahma complex. Brumby, A.M., Zraly, C.B., Horsfield, J.A., Secombe, J., Saint, R., Dingwall, A.K., Richardson, H. EMBO J. (2002) [Pubmed]
  19. Drosophila p27Dacapo expression during embryogenesis is controlled by a complex regulatory region independent of cell cycle progression. Meyer, C.A., Kramer, I., Dittrich, R., Marzodko, S., Emmerich, J., Lehner, C.F. Development (2002) [Pubmed]
  20. roughex down-regulates G2 cyclins in G1. Thomas, B.J., Zavitz, K.H., Dong, X., Lane, M.E., Weigmann, K., Finley, R.L., Brent, R., Lehner, C.F., Zipursky, S.L. Genes Dev. (1997) [Pubmed]
  21. Expression of the cyclin-dependent kinase inhibitor Dacapo is regulated by cyclin E. de Nooij, J.C., Graber, K.H., Hariharan, I.K. Mech. Dev. (2000) [Pubmed]
  22. Prospero maintains the mitotic potential of glial precursors enabling them to respond to neurons. Griffiths, R.L., Hidalgo, A. EMBO J. (2004) [Pubmed]
  23. The Toll immune-regulated Drosophila protein Fondue is involved in hemolymph clotting and puparium formation. Scherfer, C., Qazi, M.R., Takahashi, K., Ueda, R., Dushay, M.S., Theopold, U., Lemaitre, B. Dev. Biol. (2006) [Pubmed]
  24. Levels of the origin-binding protein Double parked and its inhibitor Geminin increase in response to replication stress. May, N.R., Thomer, M., Murnen, K.F., Calvi, B.R. J. Cell. Sci. (2005) [Pubmed]
  25. The Drosophila F box protein archipelago regulates dMyc protein levels in vivo. Moberg, K.H., Mukherjee, A., Veraksa, A., Artavanis-Tsakonas, S., Hariharan, I.K. Curr. Biol. (2004) [Pubmed]
  26. Expression of cyclin E or DP/E2F rescues the G1 arrest of trol mutant neuroblasts in the Drosophila larval central nervous system. Caldwell, M.C., Datta, S. Mech. Dev. (1998) [Pubmed]
  27. Analysis of Drosophila cyclin EI and II function during development: identification of an inhibitory zone within the morphogenetic furrow of the eye imaginal disc that blocks the function of cyclin EI but not cyclin EII. Crack, D., Secombe, J., Coombe, M., Brumby, A., Saint, R., Richardson, H. Dev. Biol. (2002) [Pubmed]
WikiGenes - Universities