High impact information on enc

• We show that Encore physically interacts with the proteasome, Cul1 and Cyclin E [1].
• In addition, enc mutations affect the accumulation of Gurken protein within the oocyte, leading to the production of ventralized eggs [2].
• Mutations in the encore (enc) gene of Drosophila melanogaster cause one extra round of mitosis in the germline, resulting in the formation of egg chambers with extra nurse cells [2].
• Cloning of the enc locus and generation of anti-Enc antibodies reveal that enc encodes a large novel protein that accumulates within the oocyte cytoplasm and colocalizes with grk mRNA [2].
• We argue that the enc mutant phenotypes reflect a role for Enc in the regulation of several RNA targets [2].

Biological context of enc

• Here we show that post-transcriptional regulation of Grk protein levels is required for correct pattern formation. encore (enc), a gene that functions in the regulation of germline mitosis and maintenance of oocyte identity, is also required for the accumulation of Grk protein during oogenesis [3].
• Furthermore, we demonstrate that the requirement for enc in these processes is temporally distinct from its role in germline mitosis [2].

Regulatory relationships of enc

• We present evidence that enc regulates Grk post-transcriptionally to ensure adequate levels of signaling for establishment of the anterior-posterior and dorsal-ventral axes [3].

References