The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

enc  -  encore

Drosophila melanogaster

Synonyms: BB129, CG10847, Dmel\CG10847, Enc, Protein encore, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on enc

  • We show that Encore physically interacts with the proteasome, Cul1 and Cyclin E [1].
  • In addition, enc mutations affect the accumulation of Gurken protein within the oocyte, leading to the production of ventralized eggs [2].
  • Mutations in the encore (enc) gene of Drosophila melanogaster cause one extra round of mitosis in the germline, resulting in the formation of egg chambers with extra nurse cells [2].
  • Cloning of the enc locus and generation of anti-Enc antibodies reveal that enc encodes a large novel protein that accumulates within the oocyte cytoplasm and colocalizes with grk mRNA [2].
  • We argue that the enc mutant phenotypes reflect a role for Enc in the regulation of several RNA targets [2].

Biological context of enc

  • Here we show that post-transcriptional regulation of Grk protein levels is required for correct pattern formation. encore (enc), a gene that functions in the regulation of germline mitosis and maintenance of oocyte identity, is also required for the accumulation of Grk protein during oogenesis [3].
  • Furthermore, we demonstrate that the requirement for enc in these processes is temporally distinct from its role in germline mitosis [2].

Regulatory relationships of enc

  • We present evidence that enc regulates Grk post-transcriptionally to ensure adequate levels of signaling for establishment of the anterior-posterior and dorsal-ventral axes [3].


  1. Encore facilitates SCF-Ubiquitin-proteasome-dependent proteolysis during Drosophila oogenesis. Ohlmeyer, J.T., Schüpbach, T. Development (2003) [Pubmed]
  2. Encore is a member of a novel family of proteins and affects multiple processes in Drosophila oogenesis. Van Buskirk, C., Hawkins, N.C., Schüpbach, T. Development (2000) [Pubmed]
  3. Post-transcriptional regulation of gurken by encore is required for axis determination in Drosophila. Hawkins, N.C., Van Buskirk, C., Grossniklaus, U., Schüpbach, T. Development (1997) [Pubmed]
WikiGenes - Universities